Detailed information of TA system TA023113

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /DUF1778(antitoxin)
• Location: 1743096..1743871
• Replicon: chromosome
• Accession: NC_011312
• Organism: Aliivibrio salmonicida LFI1238

Toxin (Protein)

• Gene name: -
• Uniprot ID: B6EME0
• Locus tag: VSAL_RS08705
• Protein ID: WP_012550273.1
• Coordinates: 1743368..1743871 (+)
• Length: 168 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: VSAL_RS08700
• Protein ID: WP_044583260.1
• Coordinates: 1743096..1743371 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VSAL_RS08685	1738833..1740002	+	1170	WP_012550270.1	S-methyl-5-thioribose kinase	-
VSAL_RS08690	1740065..1741711	-	1647	WP_173362140.1	methyl-accepting chemotaxis protein	-
VSAL_RS08695	1741945..1742901	+	957	WP_012549047.1	IS30-like element ISVsa7 family transposase	-
VSAL_RS08700	1743096..1743371	+	276	WP_044583260.1	DUF1778 domain-containing protein	Antitoxin
VSAL_RS08705	1743368..1743871	+	504	WP_012550273.1	GNAT family N-acetyltransferase	Toxin
VSAL_RS08710	1744160..1744405	-	246	WP_012550274.1	hypothetical protein	-
VSAL_RS08715	1744395..1744658	-	264	WP_012550275.1	BrnT family toxin	-
VSAL_RS08720	1744838..1745956	-	1119	WP_012550276.1	hypothetical protein	-
VSAL_RS08725	1745949..1746257	-	309	WP_012550277.1	hypothetical protein	-
VSAL_RS08730	1746239..1746901	-	663	WP_012550278.1	hypothetical protein	-
VSAL_RS08735	1747082..1747396	-	315	WP_012550279.1	type II toxin-antitoxin system MqsA family antitoxin	-
VSAL_RS08740	1747383..1747715	-	333	WP_023603298.1	type II toxin-antitoxin system RelE/ParE family toxin	-
VSAL_RS08745	1747924..1748373	-	450	WP_044583261.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (83-148)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-90)

Sequences

Toxin

Protein

• Length: 168 a.a.
• Molecular weight: 19038.00 Da
• Isoelectric Point: 8.4469

>T23113 WP_012550273.1 NC_011312:1743368-1743871 [Aliivibrio salmonicida LFI1238]
MNTVQLEKAKHDRNRFDCGITALNNYLKVMASQQAKKDNTRTFVLEDKQCPEHIIGYYTLTMTPIDIQDLPPKLQKKHHS
VTSGGLIARLAVDHRYKGQRFGEWLLIDALRKLLMASETVAFPVVIVDVKDGAEYFYEKYGFTAFKDADNKLFITIADIR
ASIGELI

Nucleotide

• Length: 504 bp

>T23113 NC_011312:1743368-1743871 [Aliivibrio salmonicida LFI1238]
ATGAATACTGTCCAATTAGAAAAAGCTAAACATGACCGAAACCGTTTTGATTGTGGCATTACCGCACTCAATAATTACTT
AAAAGTTATGGCAAGCCAACAAGCTAAGAAAGACAATACTCGTACTTTTGTTCTTGAAGATAAACAATGTCCTGAGCACA
TTATTGGTTATTACACATTAACAATGACACCAATTGATATTCAGGATTTACCTCCTAAATTACAAAAGAAACATCACAGT
GTAACTTCTGGTGGTTTGATTGCTCGCTTAGCCGTTGACCATAGATACAAAGGTCAGAGGTTCGGTGAATGGCTTTTGAT
TGATGCACTTAGAAAGCTATTAATGGCAAGTGAAACAGTCGCCTTCCCTGTTGTCATTGTTGATGTAAAAGATGGCGCTG
AGTATTTCTATGAAAAATACGGATTTACCGCATTCAAAGACGCTGATAACAAACTGTTTATTACAATTGCAGACATTAGA
GCCAGTATCGGTGAATTAATTTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 9938.46 Da
• Isoelectric Point: 8.6157

>AT23113 WP_044583260.1 NC_011312:1743096-1743371 [Aliivibrio salmonicida LFI1238]
MATALPRITARVDIDTQELLSQAAAIAGMSSINSFVLSAAVEKAKTIMERERALQLSQQDAMTLMTALDQPAKPNNKLQK
AASRYMDKTQE

Nucleotide

• Length: 276 bp

>AT23113 NC_011312:1743096-1743371 [Aliivibrio salmonicida LFI1238]
ATGGCTACTGCATTACCCCGTATTACAGCACGTGTAGATATTGATACACAAGAACTACTGTCTCAAGCTGCGGCCATTGC
CGGTATGTCTAGCATTAACTCATTTGTGCTTAGTGCGGCTGTAGAAAAAGCAAAAACTATTATGGAACGTGAACGAGCCC
TACAACTAAGCCAGCAAGATGCTATGACGTTAATGACTGCGTTAGACCAACCAGCTAAACCAAATAACAAATTACAAAAA
GCCGCTTCACGTTATATGGATAAAACTCAAGAATGA

Structures

Toxin

• AlphaFold DB: B6EME0