Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 838330..838990 Replicon chromosome
Accession NZ_CP090541
Organism Salmonella enterica strain 2010112-SE

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag L0F62_RS04030 Protein ID WP_000244756.1
Coordinates 838577..838990 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag L0F62_RS04025 Protein ID WP_000351186.1
Coordinates 838330..838596 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F62_RS04005 (834258) 834258..835691 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
L0F62_RS04010 (835850) 835850..836161 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
L0F62_RS04015 (836325) 836325..836984 + 660 WP_000250289.1 hemolysin III family protein -
L0F62_RS04020 (837100) 837100..838080 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
L0F62_RS04025 (838330) 838330..838596 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
L0F62_RS04030 (838577) 838577..838990 + 414 WP_000244756.1 protein YgfX Toxin
L0F62_RS04035 (839043) 839043..839564 - 522 WP_001055885.1 flavodoxin FldB -
L0F62_RS04040 (839677) 839677..840573 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
L0F62_RS04045 (840597) 840597..841310 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L0F62_RS04050 (841316) 841316..843049 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T231121 WP_000244756.1 NZ_CP090541:838577-838990 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T231121 NZ_CP126055:1959745-1960071 [Pasteurella multocida]
ATGGACAGAGTCCGATTTAATCTTACGGAAGATAGCTTCCAAGACAAGTATCTGTATGAGTATTTTTTATATGGAAGTAA
GCATAAAAATATTCCAAGTGATATAGAAAATACGCTAGCGCATAAATTAGATATGTTAGATAGCGCAAATACTTTGAATG
ATTTGCGAAGTCCACCAGGTAATAAATTGGAAAAATTGGAGCCTAAAACGAGTGGGCTATATTCTATCAGAGTGAATGTG
AAATATCGTTTAATATTTAAATATAAAGAAAGTAATTTTCCAAAAATAACAGAGTTGAGATTAGATAAACATCAATATAG
ATTATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT231121 WP_000351186.1 NZ_CP090541:838330-838596 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT231121 NZ_CP126055:1960172-1960498 [Pasteurella multocida]
ATGAGTAGAGTACAAAGAAAGCCATCAACAGTGGGTGATATTTTATTAGATGAATATTTAGTTCCACTAAATTTGAAAAT
TGCAGATTTAGCTACAATGTTAGATGTTCATCGTAATACAGCAAGTGCACTCGTTAATAATAATACTAAATTGTCTTTAG
AAATGGCACTGAAACTAGCAAAACTATTTAATACAAGTCCTGAGTTTTGGTTAAATTTACAAATGAAATTAGACTTATGG
GAAATTGAAAACAATGCTAGGTTTCAAGAAAGTTTAAAGAAAATTTTGTCTATTGATCAGCATAACCTGTTAGAAAAAAT
CGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References