231113

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4294958..4295474 Replicon chromosome
Accession NZ_CP090539
Organism Salmonella enterica strain 2016062-SE

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag L0F59_RS21050 Protein ID WP_000220578.1
Coordinates 4294958..4295242 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag L0F59_RS21055 Protein ID WP_000212724.1
Coordinates 4295232..4295474 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F59_RS21035 (4290170) 4290170..4291822 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
L0F59_RS21040 (4292231) 4292231..4294369 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
L0F59_RS21045 (4294490) 4294490..4294954 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L0F59_RS21050 (4294958) 4294958..4295242 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0F59_RS21055 (4295232) 4295232..4295474 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L0F59_RS21060 (4295552) 4295552..4297465 - 1914 WP_001212137.1 BglG family transcription antiterminator -
L0F59_RS21065 (4297482) 4297482..4298222 - 741 WP_000779263.1 KDGP aldolase family protein -
L0F59_RS21070 (4298219) 4298219..4299337 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
L0F59_RS21075 (4299321) 4299321..4300454 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T231113 WP_000220578.1 NZ_CP090539:c4295242-4294958 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T231113 NZ_CP125996:c5779172-5778765 [Gordonia sp. L191]
GTGATCCTCGACACCAGCGCCCTTCTCGCTTACTTCGACTCCGCGGAACCGCAGCACAGTGCCGTCGCCGAGATCATCGA
ATCCCACTCCGGTCCACTGGTCATTTCGCCGTTCGTCATCGCCGAACTCGACTATCTCCTACTGACCAGACACGGCACTC
GAGCCGAACAGGTGGTCCTGTCGGAATTGACTTCCGGCGCATGGGAACTGGCATCAATGACGAGGAGTCGAATCGTCACG
GCGACAGCCATCGTCGAGCGATATTCCGACATACCGATCGGCGTCACCGATGCCTCCAACATCGTCCTCGCGGACGCGTA
TCAGACTTCTTTGATTGCAACCCTCGATCATCGGCACTTCAGCATTCTTCGACTCATGGATGGATCGCCGCCGACCATCG
TTCCCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT231113 WP_000212724.1 NZ_CP090539:c4295474-4295232 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT231113 NZ_CP125996:c5779381-5779169 [Gordonia sp. L191]
ATGGCGAAGACGACCCTGTACCTACCCGACGACCTAAAACGCGCCATTGAGCTCGAAGCCCGCCGTCGTTCGATTTCGGA
GGCAGAGGTGGTGCGCGAAGCCCTCCGTGCTGCGCTCGACGGGCAGAAGCCCCGGCCGCGGGGCGGTCTGTTCGTAGGCA
GCGAGCCGATTGCCGAACGCGCTGAGGAACTGCTCGACGGGTTCGGAGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References