Detailed information of TA system TA023111

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 58377..58936
• Replicon: plasmid pVSAL840
• Accession: NC_011311
• Organism: Aliivibrio salmonicida LFI1238

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B6ET24
• Locus tag: VSAL_RS21995
• Protein ID: WP_012548891.1
• Coordinates: 58377..58655 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B6ET25
• Locus tag: VSAL_RS22000
• Protein ID: WP_012548892.1
• Coordinates: 58652..58936 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VSAL_RS21975	54700..55974	+	1275	WP_012548888.1	nucleotidyltransferase	-
VSAL_RS21980	56054..56626	+	573	WP_012548889.1	SLATT domain-containing protein	-
VSAL_RS21985	57061..57801	-	741	WP_012548890.1	IS6-like element ISVsa4 family transposase	-
VSAL_RS21990	57825..58238	+	414	WP_148234228.1	hypothetical protein	-
VSAL_RS21995	58377..58655	-	279	WP_012548891.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
VSAL_RS22000	58652..58936	-	285	WP_012548892.1	DNA-damage-inducible protein J	Antitoxin
VSAL_RS22005	59510..61699	+	2190	WP_012548893.1	glycoside hydrolase family 3 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..83540	83540
	-	flank	IS/Tn	-	-	57061..57801	740

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10811.58 Da
• Isoelectric Point: 5.1373

>T23111 WP_012548891.1 NC_011311:c58655-58377 [Aliivibrio salmonicida LFI1238]
MIFWEEESLNDREKIFEFLHDFNPEAAEKTDKIIELKVNNLLEQPLMGIQRNGIRGRILIIPEISMLISYNVSDSTIQVM
RVLHQKQKFPVA

Nucleotide

• Length: 279 bp

>T23111 NC_011311:c58655-58377 [Aliivibrio salmonicida LFI1238]
ATGATTTTTTGGGAAGAAGAATCACTTAATGACCGCGAGAAAATCTTTGAGTTTCTCCATGATTTCAACCCAGAAGCAGC
AGAAAAAACCGATAAGATAATCGAACTTAAAGTGAATAATCTTTTAGAGCAGCCGTTAATGGGAATTCAAAGGAACGGGA
TTAGAGGGCGAATTTTGATAATTCCCGAAATATCTATGCTCATATCATATAATGTTTCTGATTCGACGATCCAAGTTATG
CGAGTTCTTCATCAAAAACAAAAATTCCCCGTTGCTTAG

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10924.30 Da
• Isoelectric Point: 10.0251

>AT23111 WP_012548892.1 NC_011311:c58936-58652 [Aliivibrio salmonicida LFI1238]
METRIQFRVAEETKHLAQQMAESQGRTLSGACRKLIEQLAEQQRKAMTHDTWLSEQINTAFKKIDSGEANFIEQQHANSQ
MEHRKNKIRNRGLS

Nucleotide

• Length: 285 bp

>AT23111 NC_011311:c58936-58652 [Aliivibrio salmonicida LFI1238]
ATGGAAACTAGAATACAATTTCGTGTTGCAGAAGAAACTAAACATTTAGCTCAACAGATGGCAGAAAGCCAAGGCAGAAC
TCTTAGTGGTGCTTGCCGTAAACTTATAGAACAACTTGCAGAACAACAACGTAAAGCAATGACGCATGATACCTGGTTAA
GTGAACAAATTAACACTGCATTTAAAAAAATTGATTCTGGAGAGGCTAATTTCATTGAGCAACAACATGCCAATTCTCAG
ATGGAACACCGTAAAAATAAGATCCGTAATAGGGGATTATCATGA

Structures

Toxin

• AlphaFold DB: B6ET24

Antitoxin

• AlphaFold DB: B6ET25