Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3581782..3582402 Replicon chromosome
Accession NZ_CP090539
Organism Salmonella enterica strain 2016062-SE

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag L0F59_RS17775 Protein ID WP_001280991.1
Coordinates 3582184..3582402 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag L0F59_RS17770 Protein ID WP_000344807.1
Coordinates 3581782..3582156 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F59_RS17760 (3576921) 3576921..3578114 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L0F59_RS17765 (3578137) 3578137..3581286 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
L0F59_RS17770 (3581782) 3581782..3582156 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
L0F59_RS17775 (3582184) 3582184..3582402 + 219 WP_001280991.1 HHA domain-containing protein Toxin
L0F59_RS17780 (3582581) 3582581..3583132 + 552 WP_001278792.1 maltose O-acetyltransferase -
L0F59_RS17785 (3583249) 3583249..3583719 + 471 WP_000136181.1 YlaC family protein -
L0F59_RS17790 (3583775) 3583775..3583915 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
L0F59_RS17795 (3583921) 3583921..3584181 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
L0F59_RS17800 (3584406) 3584406..3585956 + 1551 WP_000213139.1 EAL domain-containing protein -
L0F59_RS17810 (3586187) 3586187..3586576 + 390 WP_000961285.1 MGMT family protein -
L0F59_RS17815 (3586609) 3586609..3587178 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T231108 WP_001280991.1 NZ_CP090539:3582184-3582402 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T231108 NZ_CP125992:247282-247632 [Bacillus cereus]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT231108 WP_000344807.1 NZ_CP090539:3581782-3582156 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT231108 NZ_CP125992:246990-247277 [Bacillus cereus]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References