Detailed information of TA system TA231092

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 53346..53893
• Replicon: plasmid p3
• Accession: NZ_CP090538
• Organism: Salmonella enterica strain 2016089-SE

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: L0F58_RS25325
• Protein ID: WP_013009346.1
• Coordinates: 53346..53624 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: E0WH52
• Locus tag: L0F58_RS25330
• Protein ID: WP_000079932.1
• Coordinates: 53624..53893 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0F58_RS25305 (L0F58_25305)	49347..50693	-	1347	WP_001132021.1	protein YagA	-
L0F58_RS25310 (L0F58_25310)	51047..51640	+	594	WP_001401779.1	ProQ/FINO family protein	-
L0F58_RS25315 (L0F58_25315)	51922..52509	-	588	WP_001418189.1	serine acetyltransferase	-
L0F58_RS25320 (L0F58_25320)	52854..53150	+	297	WP_001419651.1	hypothetical protein	-
L0F58_RS25325 (L0F58_25325)	53346..53624	-	279	WP_013009346.1	type II toxin-antitoxin system toxin YacB	Toxin
L0F58_RS25330 (L0F58_25330)	53624..53893	-	270	WP_000079932.1	type II toxin-antitoxin system antitoxin YacA	Antitoxin
L0F58_RS25335 (L0F58_25335)	54804..55835	-	1032	WP_000907881.1	plasmid replication initiator RepA	-
L0F58_RS25340 (L0F58_25340)	56673..57179	+	507	WP_064670812.1	transcription termination/antitermination NusG family protein	-
L0F58_RS25345 (L0F58_25345)	57319..57981	+	663	WP_005082527.1	hypothetical protein	-
L0F58_RS25350 (L0F58_25350)	58248..58391	+	144	WP_072105535.1	hypothetical protein	-
L0F58_RS25355 (L0F58_25355)	58472..58714	+	243	WP_001271734.1	PilI type IV pilus biogenesis protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	blaCTX-M-14	-	1..90380	90380
	-	flank	IS/Tn	-	-	48311..49015	704

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10748.35 Da
• Isoelectric Point: 8.4615

>T231092 WP_013009346.1 NZ_CP090538:c53624-53346 [Salmonella enterica]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
VLRVLHTAQKWP

Nucleotide

• Length: 279 bp

>T231092 NZ_CP125961:c4744876-4744640 [Pseudomonas brassicacearum]
ATGCGTACCCTATTTTTTGAAACGACTACATTCACCGACACGGTTGGCCATTACCTGACTGATGATGAGTATCGCCTGCT
TCAGTCCTATATGCTGCAGCATCCAGAGGTCGGTGACGTCATGCCACGTACCGGCGGCTTTCGTAAGCTGCGCTGGTTCG
ATGAACGTCGTGGTAAAGGGAAGCGAGGCGGGTTGCGCGTTATCTACTATTGGCTCATGAACGATCGTCAGTTCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10268.58 Da
• Isoelectric Point: 7.2055

>AT231092 WP_000079932.1 NZ_CP090538:c53893-53624 [Salmonella enterica]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVSDK

Nucleotide

• Length: 270 bp

>AT231092 NZ_CP125961:c4744535-4744221 [Pseudomonas brassicacearum]
ATGAAAAAGCGCGATCTGTTTGCCGAGATGATGCAAGGCGTCGAGGAGATGGCCGCCCACCGGGAGGGCAAGATTACCCT
TCGCCAGATATCGATCGAAGACAAACCGGTTCCCGAGGTGTCTGCCCAAGAAATCGTGGCGTTGCGCGACAAGCTCCACA
TGTCTCAAGCCGTTTTCGCCAAGAGCATCAGGACCAGTCCAGGTACGCTCAGGAACTGGGAGCAGGAGAAGTCCAAGCCT
AACGCCCAGGCGGCTTTGTTGATCAAGCTGGTCGAGAAGTTTCCAGATATGGTCGAACGGCTTGGCGCTGTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A5U8RN22