Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 84084..85707 | Replicon | plasmid p2016089-170 |
Accession | NZ_CP090536 | ||
Organism | Salmonella enterica strain 2016089-SE |
Toxin (Protein)
Gene name | hipA | Uniprot ID | H9TH67 |
Locus tag | L0F58_RS24550 | Protein ID | WP_000088046.1 |
Coordinates | 84382..85707 (+) | Length | 442 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | A0A5Z6V2D1 |
Locus tag | L0F58_RS24545 | Protein ID | WP_024136327.1 |
Coordinates | 84084..84377 (+) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L0F58_RS24520 (L0F58_24520) | 79956..81197 | + | 1242 | WP_001053338.1 | VWA domain-containing protein | - |
L0F58_RS25540 | 81288..81419 | + | 132 | WP_000374059.1 | hypothetical protein | - |
L0F58_RS24525 (L0F58_24525) | 81760..82041 | - | 282 | WP_000077926.1 | hypothetical protein | - |
L0F58_RS24530 (L0F58_24530) | 82091..82282 | - | 192 | WP_000398480.1 | hypothetical protein | - |
L0F58_RS24535 (L0F58_24535) | 82374..82715 | - | 342 | WP_001151575.1 | hypothetical protein | - |
L0F58_RS24540 (L0F58_24540) | 83088..83480 | + | 393 | WP_000341066.1 | hypothetical protein | - |
L0F58_RS24545 (L0F58_24545) | 84084..84377 | + | 294 | WP_024136327.1 | helix-turn-helix transcriptional regulator | Antitoxin |
L0F58_RS24550 (L0F58_24550) | 84382..85707 | + | 1326 | WP_000088046.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
L0F58_RS24555 (L0F58_24555) | 85768..85974 | + | 207 | WP_000134171.1 | hypothetical protein | - |
L0F58_RS24560 (L0F58_24560) | 86076..86486 | + | 411 | WP_000985911.1 | hypothetical protein | - |
L0F58_RS24565 (L0F58_24565) | 86499..87314 | + | 816 | WP_001572439.1 | HNH endonuclease signature motif containing protein | - |
L0F58_RS24570 (L0F58_24570) | 87568..87993 | + | 426 | WP_001043843.1 | hypothetical protein | - |
L0F58_RS24575 (L0F58_24575) | 88447..88683 | + | 237 | Protein_86 | type I restriction-modification system subunit M N-terminal domain-containing protein | - |
L0F58_RS24580 (L0F58_24580) | 88738..89037 | + | 300 | WP_001572440.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / aac(3)-IVa / aph(4)-Ia / sul2 / floR / oqxB / oqxA | - | 1..170071 | 170071 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 442 a.a. Molecular weight: 50249.20 Da Isoelectric Point: 6.1927
>T231091 WP_000088046.1 NZ_CP090536:84382-85707 [Salmonella enterica]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
Download Length: 1326 bp
>T231091 NZ_CP125961:c1576871-1576596 [Pseudomonas brassicacearum]
ATGGAGTTGAAGTGGACCAGCAAGGCGCTTTCCGACATTGCTCGACTTTATGAATTTCTGGCGGCGGTGAATCAACCCGC
GGCCGCACGAACAGTGCAACAACTCACAGCCGCGCCGACCTCTCTGCTGGCCAACCCGCGCATTGGTGAACGCCTGGAAG
AGTTCGAACCTCGAGACGTGCGCAGAATCCAAGTGGGGCGCTACGAAATGCGCTATGAAATAGCCGGTTCCACCCTGTAC
CTGCTACGCCTGTGGCACACACGTGAGGATCGATGA
ATGGAGTTGAAGTGGACCAGCAAGGCGCTTTCCGACATTGCTCGACTTTATGAATTTCTGGCGGCGGTGAATCAACCCGC
GGCCGCACGAACAGTGCAACAACTCACAGCCGCGCCGACCTCTCTGCTGGCCAACCCGCGCATTGGTGAACGCCTGGAAG
AGTTCGAACCTCGAGACGTGCGCAGAATCCAAGTGGGGCGCTACGAAATGCGCTATGAAATAGCCGGTTCCACCCTGTAC
CTGCTACGCCTGTGGCACACACGTGAGGATCGATGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10946.35 Da Isoelectric Point: 10.0925
>AT231091 WP_024136327.1 NZ_CP090536:84084-84377 [Salmonella enterica]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
Download Length: 294 bp
>AT231091 NZ_CP125961:c1577143-1576871 [Pseudomonas brassicacearum]
ATGACAACCACCGCGAAAACCCGGTCGGTCACAGCTCACGTCCCGGTGCACCTGGCCGAAAAAGTCGACCTGATGGCCGA
GCGCCTCGAGCGTTCCAGGAACTGGATCGTCAAACAAGCGCTATCTGCCTGGATCGAGCAGGAGGAGGAGCGAAGCCGCC
TGACCCATGAGGCCTTGGCCGATGTTGACGCCGGCCGAGTGATTGACCACCAGGCTGTCCAGGCTTGGGCCGATAGTCTC
AGCACCGACGCCCCGTTACCGGTACCGCGCTGA
ATGACAACCACCGCGAAAACCCGGTCGGTCACAGCTCACGTCCCGGTGCACCTGGCCGAAAAAGTCGACCTGATGGCCGA
GCGCCTCGAGCGTTCCAGGAACTGGATCGTCAAACAAGCGCTATCTGCCTGGATCGAGCAGGAGGAGGAGCGAAGCCGCC
TGACCCATGAGGCCTTGGCCGATGTTGACGCCGGCCGAGTGATTGACCACCAGGCTGTCCAGGCTTGGGCCGATAGTCTC
AGCACCGACGCCCCGTTACCGGTACCGCGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3T0VBU1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5Z6V2D1 |