Detailed information of TA system TA023109

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5236377..5238058
• Replicon: chromosome
• Accession: NC_011283
• Organism: Klebsiella pneumoniae 342

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: KPK_RS24585
• Protein ID: WP_012543157.1
• Coordinates: 5236377..5237252 (-)
• Length: 292 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A0B7GCX3
• Locus tag: KPK_RS24590
• Protein ID: WP_008807257.1
• Coordinates: 5237300..5238058 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KPK_RS24565	5231683..5233203	+	1521	WP_012543153.1	sugar ABC transporter ATP-binding protein	-
KPK_RS24570	5233200..5234198	+	999	WP_012543154.1	ribose ABC transporter permease	-
KPK_RS24575	5234229..5235170	+	942	WP_012543155.1	ABC transporter substrate-binding protein	-
KPK_RS24580	5235245..5236252	+	1008	WP_012543156.1	carbohydrate kinase family protein	-
KPK_RS24585	5236377..5237252	-	876	WP_012543157.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
KPK_RS24590	5237300..5238058	-	759	WP_008807257.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
KPK_RS24595	5238143..5238871	-	729	WP_012543158.1	response regulator transcription factor	-
KPK_RS24605	5239144..5241291	+	2148	WP_012543160.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
KPK_RS24610	5241997..5242683	+	687	WP_008807260.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (7-264)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 292 a.a.
• Molecular weight: 33088.17 Da
• Isoelectric Point: 5.4637

>T23109 WP_012543157.1 NC_011283:c5237252-5236377 [Klebsiella variicola]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRTIALPHIRDALARIAANLQQQAGMNAVLQANRSDE
MRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKSCFTQQDIDFLLSFK
RGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 876 bp

>T23109 NC_011283:c5237252-5236377 [Klebsiella variicola]
ATGCAGGTTTTACCCTATGTTGCCGTCGAACGGGAATTTGCGCTGAAAGGTGGCACGGCAATCAATCTCTTTATCCGTGA
TTTCCCACGATTATCGGTGGATATCGACCTCGCCTGGGTGCCCCTGGAAAGCAGAACGATCGCTTTACCTCATATACGGG
ATGCGCTTGCACGTATTGCCGCTAATCTGCAACAACAGGCAGGTATGAACGCTGTATTACAAGCTAATCGTTCCGATGAG
ATGCGTGTCGTTGTTACTACCGATAGCGCACAAATAAAGATAGAGGTCTCACCGGTCGCACGGGGAACATTATATCCACC
ACAGGAGCGAGAGGTGGTGGGGGCGGTAGAGGACGTTTTTGGCTATGCCAGCCTTCCGGTGGTTTCGTTGCCCGATCTCT
ACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCATCCCAGAGATTTTTATGATGTGAAATTACTTCTTGATGCGCAG
GAGCTTAACCGTCCCATTTTCAATGGGTTTATCGCGTATTTACTTAGCCATAATCGGCCTCTGGCTGAAGTGCTTAGTCC
TCGCTGGAAAGATATTGCTGAACCCTTTTACCGTGAATTCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGA
CAGCAGTCCCCTACAGGATGATTGATGCGTTAAAATCCTGTTTCACGCAACAGGATATCGATTTTTTGCTGTCATTTAAA
CGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAACACGTATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATAT
TCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAGATAAACTGGAAAAGGTGTTGGCCGAGTGGCGCAGTTAG

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28653.01 Da
• Isoelectric Point: 10.1988

>AT23109 WP_008807257.1 NC_011283:c5238058-5237300 [Klebsiella variicola]
MPSKLNWLLQNSAPGDVILQSWLSRHAISPSLAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVTLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT23109 NC_011283:c5238058-5237300 [Klebsiella variicola]
ATGCCATCAAAATTAAACTGGCTGCTGCAAAACAGTGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCGGCATGC
CATCTCGCCCTCTCTGGCCTTTAAATACACGCAAAGTGGCTGGTTAAAAAAACGAGGCAACGGCGTATACGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTAGCCGCTCCGGTGTATGTCGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGTCGTTCACACTATCTACAGCTCAAACAAAACCAGTGCTGGTTGAGTATGGAAAATAAAGCGCT
GCTGCCAAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGCAAAAACTGCCGGTGCTGGATGATA
AATACCGCGTAACGCTTGATGTAAAAGGGAAAAGACTCACCGGCAGTGCGCCGGAACTGGCTGCTTACGAGTTGTTGAGC
GCGGTACCGGGGACCCTCTCATTTAACCACGCGGCAGAGCTTTTCCAGGGACTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTGCTTTCTGTCAGCCAGTCCGTGCAGACCAAGCGTTTGTATCTCTTTTTCGCCAGTTTTTACGAGCATGGTTGGC
TCAGACGAATCGATAGCCAAAAAATCGATCTGGGTGCGGGTAAGCGGCAAATCGTGGTAAATGGCAAGTTCAATGCTCAA
TATCAAATCACTGTGCCTGAACGCTTTCAAAAGGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0B7GCX3