Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4228245..4228761 Replicon chromosome
Accession NZ_CP090535
Organism Salmonella enterica strain 2016089-SE

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag L0F58_RS20645 Protein ID WP_000220578.1
Coordinates 4228245..4228529 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag L0F58_RS20650 Protein ID WP_000212724.1
Coordinates 4228519..4228761 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F58_RS20630 (4223457) 4223457..4225109 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
L0F58_RS20635 (4225518) 4225518..4227656 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
L0F58_RS20640 (4227777) 4227777..4228241 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L0F58_RS20645 (4228245) 4228245..4228529 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0F58_RS20650 (4228519) 4228519..4228761 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L0F58_RS20655 (4228839) 4228839..4230752 - 1914 WP_001212137.1 BglG family transcription antiterminator -
L0F58_RS20660 (4230769) 4230769..4231509 - 741 WP_000779263.1 KDGP aldolase family protein -
L0F58_RS20665 (4231506) 4231506..4232624 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
L0F58_RS20670 (4232608) 4232608..4233741 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T231087 WP_000220578.1 NZ_CP090535:c4228529-4228245 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T231087 NZ_CP125957:c2207085-2206777 [Pseudomonas sp. G2-4]
ATGAGCCAACACCTGACGACATTTGACATGGCGGCACTACTCGATAGCGATGAAGCGATCAGTGAATACCTTTCTCAGGT
GTTGGCTGATGGTGATAGCGAGGAGTTTCTCCGAGCGATCGGCTATGTAGCCAAGGCCCGAGGCATGGCGCAGATCGCTA
AAGACTCTGGCATGGGACGAGAAAGCTTGTACAAGGCGTTCGCACCCGGATCAAAACCGAGATTCGATACCGTACTCAAG
GTCATTCATGCGCTAGGTATTGATCTTCATGCGCAGCCTGGGCATGCAGCTAATCATTCACCGGTCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT231087 WP_000212724.1 NZ_CP090535:c4228761-4228519 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT231087 NZ_CP125957:c2207375-2207088 [Pseudomonas sp. G2-4]
ATCTCATCAAAACAAACGCAGACGTTCACTGCTTGGCATTCATCGATCCGTGATCTGCGAGCAAAAATCGCTATCGCCCG
CCGCATTGATCGCGCTGCAGCAGGTAACCTGAGCGATGTAAAACCTGTCGGTGATGGTATTTCAGAATTGCGTGTGGATG
TAGGCGCTGGCTACCGGGTCTATTTCACCCTGCGCGGTGGAGTGGTCATCGTGCTATTGGCTGGTGGTGACAAGTCTTCA
CAGAGTGCTGATATCCGGCGAGCGAAGAAATTGGCAAAGGAGATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References