Detailed information of TA system TA231082

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3515070..3515690
• Replicon: chromosome
• Accession: NZ_CP090535
• Organism: Salmonella enterica strain 2016089-SE

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: L0F58_RS17365
• Protein ID: WP_001280991.1
• Coordinates: 3515472..3515690 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: L0F58_RS17360
• Protein ID: WP_000344807.1
• Coordinates: 3515070..3515444 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0F58_RS17350 (3510209)	3510209..3511402	+	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
L0F58_RS17355 (3511425)	3511425..3514574	+	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
L0F58_RS17360 (3515070)	3515070..3515444	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
L0F58_RS17365 (3515472)	3515472..3515690	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
L0F58_RS17370 (3515869)	3515869..3516420	+	552	WP_001278792.1	maltose O-acetyltransferase	-
L0F58_RS17375 (3516537)	3516537..3517007	+	471	WP_000136181.1	YlaC family protein	-
L0F58_RS17380 (3517063)	3517063..3517203	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
L0F58_RS17385 (3517209)	3517209..3517469	-	261	WP_000801415.1	type B 50S ribosomal protein L31	-
L0F58_RS17390 (3517694)	3517694..3519244	+	1551	WP_000213139.1	EAL domain-containing protein	-
L0F58_RS17400 (3519475)	3519475..3519864	+	390	WP_000961285.1	MGMT family protein	-
L0F58_RS17405 (3519897)	3519897..3520466	-	570	WP_000779803.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T231082 WP_001280991.1 NZ_CP090535:3515472-3515690 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T231082 NZ_CP125948:8850-9110 [Comamonas sp. ZM22]
TTGGCTTGGCGCATTGAGTTTGAAGACACCGCTCTCAAAGAGCTGGCTAAGCTGGACAAACAAGTAGCCCGACGCATCCT
AGCCTTCCTGCGGGAGCGGGTGGCAGTGCTTGATGATCCGCCCAGCGTGGGGGAGGCTTTAAAGGGCTCAACGCTGGGGG
AGTTCTGGAAATACCGCATGGGCGGCTGCCGCATCATCACCAGCATCGAGGATGGTGTTATGCGGATTTTGGTGTTGAAG
GTGGGCAACCAAAGTAAATGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT231082 WP_000344807.1 NZ_CP090535:3515070-3515444 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT231082 NZ_CP125948:8639-8866 [Comamonas sp. ZM22]
ATGGCCGTTTCACTACGTTTGCCTGAAGACCTGAGTCAGCGCCTGAGCAATTTGGCAGCGCAAACAGGCCGCTCCAAGAC
CTTCTACATGCTCGAAGCCATCAAGCAGCACATTGATGACCTGGAAGACTTGTACCTGGCAGAGCAGCGCTTGCTGGACG
TGCGTGCTGGGCGCGCGGTGACGCATTCAATCGATGACGTGGAGCGCAGTCTTGGCTTGGCGCATTGA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0