23108

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 5017762..5019482 Replicon chromosome
Accession NC_011283
Organism Klebsiella pneumoniae 342

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag KPK_RS23575 Protein ID WP_012543060.1
Coordinates 5018826..5019482 (-) Length 219 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag KPK_RS23570 Protein ID WP_012543059.1
Coordinates 5017762..5018829 (-) Length 356 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPK_RS23550 5013262..5013513 + 252 WP_012543056.1 hypothetical protein -
KPK_RS29490 5013561..5013852 + 292 Protein_4781 hypothetical protein -
KPK_RS23560 5013930..5014646 - 717 WP_012543057.1 M48 family metallopeptidase -
KPK_RS23565 5014646..5017741 - 3096 WP_012543058.1 HsdR family type I site-specific deoxyribonuclease -
KPK_RS23570 5017762..5018829 - 1068 WP_012543059.1 macro domain-containing protein Antitoxin
KPK_RS23575 5018826..5019482 - 657 WP_012543060.1 DUF4433 domain-containing protein Toxin
KPK_RS23580 5019495..5020844 - 1350 WP_041165470.1 restriction endonuclease subunit S -
KPK_RS23585 5020856..5023300 - 2445 WP_012543062.1 type I restriction-modification system subunit M -
KPK_RS23590 5023340..5023579 - 240 WP_012543063.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5001642..5025206 23564


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(17-217)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 219 a.a.        Molecular weight: 25158.60 Da        Isoelectric Point: 7.0165

>T23108 WP_012543060.1 NC_011283:c5019482-5018826 [Klebsiella variicola]
MAYDYSANLNPEKALIWRIVHRDNIPWILDNGLHCGNSPVQAANWINIGNPELIDKRAGHPVPAGTGGTLHDYVPFYFTP
FSPMLMNIHSGRGGIKQRPNEEIVILVSSLRHVATQNVPFVFTDSHAYYNLANYYTDLNNLHRIDWPILQARDFRRDQDD
LAKFERYQAEALIWQHCPITLLVGMICYNDGVRLQLEQWLSQRNLTMPVHARAGWYFS

Download         Length: 657 bp

>T23108 NC_011283:c5019482-5018826 [Klebsiella variicola]
ATGGCTTATGATTACAGCGCTAATCTCAACCCGGAAAAAGCCCTGATCTGGCGCATTGTCCATCGGGACAATATCCCGTG
GATACTGGACAACGGCCTGCACTGCGGCAACAGCCCGGTGCAGGCCGCAAACTGGATCAATATCGGCAACCCGGAGCTTA
TCGACAAACGCGCCGGGCATCCGGTGCCTGCCGGGACGGGCGGGACGCTGCATGACTATGTGCCGTTTTACTTTACCCCC
TTCTCACCGATGCTGATGAATATCCACAGTGGACGCGGCGGCATTAAGCAACGTCCCAACGAAGAAATCGTCATTCTGGT
CAGCAGCCTGCGACACGTGGCTACACAAAACGTCCCCTTCGTGTTTACCGACAGCCACGCCTACTATAATCTGGCGAATT
ACTATACCGATCTAAACAATCTGCACCGGATCGACTGGCCCATTTTACAGGCGCGGGATTTCCGTCGCGATCAGGACGAT
CTTGCCAAGTTTGAACGCTATCAGGCCGAGGCGTTAATCTGGCAGCACTGCCCCATCACGCTGCTGGTCGGGATGATTTG
TTACAACGATGGCGTCAGGTTACAATTAGAGCAATGGCTGTCGCAACGCAATCTGACAATGCCCGTTCACGCACGGGCCG
GGTGGTACTTCTCATGA

Antitoxin


Download         Length: 356 a.a.        Molecular weight: 40915.13 Da        Isoelectric Point: 5.7103

>AT23108 WP_012543059.1 NC_011283:c5018829-5017762 [Klebsiella variicola]
MMTYTQGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPDNMKAYALACKQKQVMTGKMFITETGELMGPRWIVNFPTK
QHWRADSRMEWIEDGLQDLRRFLIEENVRSIAIPPLGAGNGGLNWPDVRTRIESALGDLQDTEILIYEPTEKYQNVAKST
GVKKLTPARAMIAELVRRYWVLGMECSLLEIQKLAWLLQRAIEQHQQEDVLKLRFEAHYYGPYAPNLNHLLNALDGTYLK
AEKRIPDSQPLDVIWFNDREKEHVNLWLNSEAKEWLPALEQVSQLIDGFESPFGLELLATVDWLLTRGECQPTLDSVKEG
LHQWPAGERWANRKMKLFDDKNLQFAINRVMEFHC

Download         Length: 1068 bp

>AT23108 NC_011283:c5018829-5017762 [Klebsiella variicola]
ATGATGACATATACACAAGGCAATTTACTGGACGCGCCCGTGGAAGCACTGGTGAATACGGTGAATACCGTCGGTGTCAT
GGGTAAAGGCATCGCGCTGATGTTCAAAGAGCGCTTCCCCGACAATATGAAAGCCTATGCCCTCGCCTGCAAACAAAAGC
AGGTCATGACCGGCAAGATGTTTATTACCGAAACCGGCGAACTAATGGGGCCGCGCTGGATCGTCAACTTCCCCACCAAG
CAACACTGGCGCGCCGACTCCCGCATGGAGTGGATTGAAGACGGCTTGCAGGACTTACGTCGCTTTTTGATCGAAGAGAA
CGTGCGGTCCATCGCTATTCCCCCGCTGGGTGCGGGCAACGGCGGACTGAACTGGCCGGACGTCCGGACGCGAATTGAAT
CTGCGCTGGGCGACCTTCAGGACACAGAAATCCTGATTTATGAGCCCACCGAAAAATACCAGAATGTCGCCAAGAGCACC
GGTGTAAAAAAGCTCACCCCCGCCAGAGCGATGATCGCTGAACTGGTGCGCCGCTACTGGGTGCTGGGCATGGAGTGCAG
CCTGCTGGAAATTCAGAAGCTGGCATGGCTGTTACAACGCGCCATTGAACAGCATCAGCAGGAAGACGTGCTAAAACTAC
GGTTTGAGGCGCACTATTACGGCCCGTATGCCCCCAACCTGAACCATCTGCTTAACGCGCTGGATGGCACTTATCTGAAA
GCCGAGAAACGCATCCCGGACAGCCAACCGCTGGACGTGATCTGGTTTAACGATCGGGAAAAAGAACACGTCAACCTCTG
GCTTAACAGCGAAGCCAAAGAGTGGTTACCGGCGCTTGAGCAGGTCAGCCAGTTGATTGACGGTTTTGAATCGCCGTTTG
GTCTGGAGCTGCTGGCGACCGTTGACTGGCTGCTGACTCGGGGAGAATGCCAGCCCACGCTGGATTCAGTGAAAGAGGGG
CTACACCAGTGGCCTGCCGGGGAACGCTGGGCCAACCGCAAGATGAAGCTCTTTGACGATAAAAATCTGCAATTCGCCAT
AAACCGCGTGATGGAGTTCCATTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References