231072

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1057709..1058369 Replicon chromosome
Accession NZ_CP090535
Organism Salmonella enterica strain 2016089-SE

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag L0F58_RS05130 Protein ID WP_000244756.1
Coordinates 1057709..1058122 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag L0F58_RS05135 Protein ID WP_000351186.1
Coordinates 1058103..1058369 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F58_RS05110 (1053650) 1053650..1055383 - 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -
L0F58_RS05115 (1055389) 1055389..1056102 - 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L0F58_RS05120 (1056126) 1056126..1057022 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
L0F58_RS05125 (1057135) 1057135..1057656 + 522 WP_001055885.1 flavodoxin FldB -
L0F58_RS05130 (1057709) 1057709..1058122 - 414 WP_000244756.1 protein YgfX Toxin
L0F58_RS05135 (1058103) 1058103..1058369 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
L0F58_RS05140 (1058619) 1058619..1059599 + 981 WP_000874172.1 tRNA-modifying protein YgfZ -
L0F58_RS05145 (1059715) 1059715..1060374 - 660 WP_000250289.1 hemolysin III family protein -
L0F58_RS05150 (1060538) 1060538..1060849 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
L0F58_RS05155 (1061008) 1061008..1062441 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T231072 WP_000244756.1 NZ_CP090535:c1058122-1057709 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T231072 NZ_CP125946:907939-908130 [Rothia sp. SD9660Na]
ATCGTTAATCTTCTGGCTACAGAGCAAGAGTTACCTCCCCGAGACAGAGACCATGCGCCTACTGGGAATTTTTCAGGCAT
GAGAGGGTGCCACATTGCGCCGGACTGGTTGCTCATCTATGAAAAAGACGATGGTGTTTTGGCCCTGTTGCTGATCCGAA
CCGGCTCTCACTCAGACTTATTCAAGGAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT231072 WP_000351186.1 NZ_CP090535:c1058369-1058103 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT231072 NZ_CP125946:907576-907848 [Rothia sp. SD9660Na]
ATGTCTACATCAACTATTAGTGTTCGTACTGATTCGGCCGTTAATGGCGAGGCTGAGGAGCTTTTCGCTGAGCTTGGCTT
GAACCTTTCAACGGCTGTCAACATGTTTTTACGGCAGAGTATCCTGGAGCGCCGTATCCCCTTTGAAGTGACGACTAACG
TGCCGACAGCGGAGACCGTTGCCTCGATCGAAGAGGGGCGCAGGCTCTTGGTCGACGATAGGGCGGAGACTTTCGAGAGC
GTCGAGGCGCTGAGAAAAGCTCTAGACGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References