Detailed information of TA system TA023107

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ypjF-yeeU/CbtA-CbeA
• Location: 4983661..4984217
• Replicon: chromosome
• Accession: NC_011283
• Organism: Klebsiella pneumoniae 342

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: KPK_RS29475
• Protein ID: WP_123809107.1
• Coordinates: 4983661..4983816 (-)
• Length: 52 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: KPK_RS23420
• Protein ID: WP_012543031.1
• Coordinates: 4983861..4984217 (-)
• Length: 119 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KPK_RS29465	4979268..4979381	+	114	WP_012543025.1	hypothetical protein	-
KPK_RS23405	4979811..4980938	+	1128	WP_012543027.1	PAAR domain-containing protein	-
KPK_RS23410	4980928..4981191	+	264	WP_004192273.1	hypothetical protein	-
KPK_RS30795	4981337..4981471	+	135	Protein_4746	transposase	-
KPK_RS30800	4981484..4981594	-	111	Protein_4747	DUF4102 domain-containing protein	-
KPK_RS30805	4982548..4982802	-	255	WP_012543029.1	hypothetical protein	-
KPK_RS30810	4982892..4983410	-	519	WP_012543030.1	hypothetical protein	-
KPK_RS29475	4983661..4983816	-	156	WP_123809107.1	TA system toxin CbtA family protein	Toxin
KPK_RS23420	4983861..4984217	-	357	WP_012543031.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
KPK_RS29480	4984243..4984464	-	222	WP_012543032.1	DUF987 domain-containing protein	-
KPK_RS23425	4984461..4985003	-	543	WP_041165411.1	DNA repair protein RadC	-
KPK_RS23430	4985016..4985459	-	444	WP_012543034.1	antirestriction protein	-
KPK_RS23435	4985490..4986311	-	822	WP_012543035.1	DUF945 domain-containing protein	-
KPK_RS23440	4986431..4986904	-	474	WP_012543036.1	hypothetical protein	-
KPK_RS23445	4986976..4987428	-	453	WP_026094405.1	hypothetical protein	-
KPK_RS23450	4987464..4988180	-	717	WP_012543038.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4976683..4988180	11497

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (2-51)

Antitoxin

• Antitoxin CbeA (17-117)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5814.63 Da
• Isoelectric Point: 6.0341

>T23107 WP_123809107.1 NC_011283:c4983816-4983661 [Klebsiella variicola]
MRAAKSFLSPAAIWQMLLTHLLEQHYGLTLNDTSFSDETVTQEHFTIGIHL

Nucleotide

• Length: 156 bp

>T23107 NC_011283:c4983816-4983661 [Klebsiella variicola]
CTGCGTGCAGCGAAGTCATTCCTGTCACCTGCCGCTATCTGGCAAATGTTACTTACCCATCTGCTTGAACAGCACTATGG
TCTAACGCTAAACGATACATCTTTCAGTGATGAAACCGTTACACAGGAACATTTCACTATAGGTATCCATCTCTGA

Antitoxin

Protein

• Length: 119 a.a.
• Molecular weight: 13113.91 Da
• Isoelectric Point: 6.4736

>AT23107 WP_012543031.1 NC_011283:c4984217-4983861 [Klebsiella variicola]
MNNHSESGAIPENPPCKQWGLKSTITPCFGARLVQEGDRLHFLADRAGFNGAFSDEHVLRLDQAFPLILKQLELMLTSGE
LSPRHQHCVTLYHNGLICDADTLGSCGYVYIAVYPTQR

Nucleotide

• Length: 357 bp

>AT23107 NC_011283:c4984217-4983861 [Klebsiella variicola]
ATGAACAATCACTCAGAATCCGGTGCCATACCGGAGAATCCCCCCTGCAAACAGTGGGGGCTAAAGAGTACGATCACACC
CTGTTTTGGAGCTCGGCTGGTGCAAGAAGGCGACCGCCTGCATTTTCTCGCTGACCGCGCCGGGTTTAACGGTGCTTTCA
GCGACGAGCATGTGTTGCGCCTCGACCAGGCCTTTCCGTTGATACTCAAGCAGCTGGAGCTGATGCTCACCAGCGGAGAA
CTCTCTCCCCGCCATCAGCACTGTGTCACCCTCTATCACAACGGACTCATCTGCGACGCCGATACGCTTGGTAGTTGTGG
TTACGTATACATCGCTGTTTATCCCACTCAACGTTAA