231063

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4582757..4583517 Replicon chromosome
Accession NZ_CP090533
Organism Salmonella enterica strain 2017005-SE

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag L0F61_RS22625 Protein ID WP_000533909.1
Coordinates 4582757..4583242 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag L0F61_RS22630 Protein ID WP_000965886.1
Coordinates 4583230..4583517 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F61_RS22595 (4577827) 4577827..4578489 + 663 WP_000747548.1 OmpA family lipoprotein -
L0F61_RS22600 (4578708) 4578708..4579682 + 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
L0F61_RS22605 (4579732) 4579732..4580442 - 711 WP_000190524.1 DUF3053 domain-containing protein -
L0F61_RS22610 (4580881) 4580881..4581171 + 291 WP_000455790.1 HTH-type transcriptional regulator -
L0F61_RS22615 (4581460) 4581460..4581672 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
L0F61_RS22620 (4581846) 4581846..4582385 + 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
L0F61_RS22625 (4582757) 4582757..4583242 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
L0F61_RS22630 (4583230) 4583230..4583517 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
L0F61_RS22635 (4583695) 4583695..4584162 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
L0F61_RS22640 (4584334) 4584334..4584609 - 276 Protein_4423 IS3 family transposase -
L0F61_RS22645 (4584791) 4584791..4586860 - 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
L0F61_RS22650 (4586870) 4586870..4587781 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
L0F61_RS22655 (4587920) 4587920..4588222 - 303 WP_000605590.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T231063 WP_000533909.1 NZ_CP090533:c4583242-4582757 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T231063 NZ_CP125903:c2122614-2122438 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT231063 WP_000965886.1 NZ_CP090533:c4583517-4583230 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT231063 NZ_CP125903:2122315-2122370 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2JDX2

References