231049

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2290653..2291175 Replicon chromosome
Accession NZ_CP090533
Organism Salmonella enterica strain 2017005-SE

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag L0F61_RS11295 Protein ID WP_000221343.1
Coordinates 2290653..2290937 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag L0F61_RS11300 Protein ID WP_000885424.1
Coordinates 2290927..2291175 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F61_RS11275 (2286728) 2286728..2288236 - 1509 WP_000199411.1 FAD-dependent oxidoreductase -
L0F61_RS11280 (2288281) 2288281..2288769 + 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
L0F61_RS11285 (2288962) 2288962..2290041 + 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
L0F61_RS11290 (2290093) 2290093..2290482 - 390 WP_000194089.1 RidA family protein -
L0F61_RS11295 (2290653) 2290653..2290937 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0F61_RS11300 (2290927) 2290927..2291175 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L0F61_RS11305 (2291327) 2291327..2291542 + 216 WP_000206207.1 hypothetical protein -
L0F61_RS11310 (2291532) 2291532..2291864 + 333 WP_000253154.1 DUF1493 family protein -
L0F61_RS11315 (2292007) 2292007..2292915 + 909 WP_010989018.1 hypothetical protein -
L0F61_RS11320 (2292971) 2292971..2293685 - 715 Protein_2209 helix-turn-helix domain-containing protein -
L0F61_RS11325 (2294493) 2294493..2295959 - 1467 WP_000987828.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T231049 WP_000221343.1 NZ_CP090533:c2290937-2290653 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T231049 NZ_CP125901:1850025-1850120 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT231049 WP_000885424.1 NZ_CP090533:c2291175-2290927 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT231049 NZ_CP125901:c1850205-1850148 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References