231048

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1241322..1241942 Replicon chromosome
Accession NZ_CP090533
Organism Salmonella enterica strain 2017005-SE

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag L0F61_RS06025 Protein ID WP_001280991.1
Coordinates 1241322..1241540 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag L0F61_RS06030 Protein ID WP_000344807.1
Coordinates 1241568..1241942 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F61_RS05985 (1236546) 1236546..1237115 + 570 WP_000779803.1 YbaY family lipoprotein -
L0F61_RS05990 (1237148) 1237148..1237537 - 390 WP_000961285.1 MGMT family protein -
L0F61_RS06000 (1237768) 1237768..1239318 - 1551 WP_000213139.1 EAL domain-containing protein -
L0F61_RS06005 (1239543) 1239543..1239803 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
L0F61_RS06010 (1239809) 1239809..1239949 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
L0F61_RS06015 (1240005) 1240005..1240475 - 471 WP_000136181.1 YlaC family protein -
L0F61_RS06020 (1240592) 1240592..1241143 - 552 WP_001278792.1 maltose O-acetyltransferase -
L0F61_RS06025 (1241322) 1241322..1241540 - 219 WP_001280991.1 HHA domain-containing protein Toxin
L0F61_RS06030 (1241568) 1241568..1241942 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
L0F61_RS06035 (1242438) 1242438..1245587 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
L0F61_RS06040 (1245610) 1245610..1246803 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T231048 WP_001280991.1 NZ_CP090533:c1241540-1241322 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T231048 NZ_CP125901:c827724-827536 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT231048 WP_000344807.1 NZ_CP090533:c1241942-1241568 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT231048 NZ_CP125901:c828013-827753 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References