Detailed information of TA system TA231042

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 359897..360678
• Replicon: chromosome
• Accession: NZ_CP090533
• Organism: Salmonella enterica strain 2017005-SE

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: E8X9W8
• Locus tag: L0F61_RS01780
• Protein ID: WP_000626099.1
• Coordinates: 360187..360678 (+)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: B5R979
• Locus tag: L0F61_RS01775
• Protein ID: WP_001110452.1
• Coordinates: 359897..360190 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0F61_RS01745 (356221)	356221..357126	+	906	WP_001268200.1	YjiK family protein	-
L0F61_RS01750 (357420)	357420..357689	-	270	WP_010989096.1	hypothetical protein	-
L0F61_RS01755 (357697)	357697..357912	-	216	WP_001595136.1	hypothetical protein	-
L0F61_RS01760 (357935)	357935..358222	-	288	WP_001269916.1	transcriptional regulator RtsB	-
L0F61_RS01765 (358219)	358219..359094	-	876	WP_000921674.1	AraC family transcriptional regulator	-
L0F61_RS01770 (359359)	359359..359580	-	222	WP_001576552.1	hypothetical protein	-
L0F61_RS01775 (359897)	359897..360190	+	294	WP_001110452.1	DUF1778 domain-containing protein	Antitoxin
L0F61_RS01780 (360187)	360187..360678	+	492	WP_000626099.1	GNAT family N-acetyltransferase	Toxin
L0F61_RS01785 (360926)	360926..361678	-	753	WP_000842434.1	non-specific acid phosphatase	-
L0F61_RS01790 (361781)	361781..361855	-	75	Protein_344	porin family protein	-
L0F61_RS01795 (362888)	362888..363265	-	378	WP_000916345.1	EthD family reductase	-
L0F61_RS01800 (363337)	363337..363669	+	333	WP_001165471.1	MerR family transcriptional regulator	-
L0F61_RS01805 (363760)	363760..363837	+	78	Protein_347	helix-turn-helix domain-containing protein	-
L0F61_RS01815 (364108)	364108..364683	-	576	WP_001188509.1	transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (85-145)

Antitoxin

• Vibrio phage ICP1, Orf50 (14-88)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 17646.39 Da
• Isoelectric Point: 6.8437

>T231042 WP_000626099.1 NZ_CP090533:360187-360678 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Nucleotide

• Length: 492 bp

>T231042 NZ_CP125899:939186-939338 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGAGAGTCAGTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10977.61 Da
• Isoelectric Point: 8.6141

>AT231042 WP_001110452.1 NZ_CP090533:359897-360190 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Nucleotide

• Length: 294 bp

>AT231042 NZ_CP125899:938562-939161 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATGTAG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
CAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Toxin

• PDB: 7AK7

Antitoxin

• AlphaFold DB: A0A5I1DGA4