Detailed information of TA system TA231034

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 4459570..4460351
• Replicon: chromosome
• Accession: NZ_CP090529
• Organism: Salmonella enterica strain 2008079-SE

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: E8X9W8
• Locus tag: L0F60_RS21880
• Protein ID: WP_000626099.1
• Coordinates: 4459570..4460061 (-)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: B5R979
• Locus tag: L0F60_RS21885
• Protein ID: WP_001110452.1
• Coordinates: 4460058..4460351 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0F60_RS21840 (4454756)	4454756..4454998	-	243	WP_197603740.1	hypothetical protein	-
L0F60_RS21845 (4454995)	4454995..4455351	-	357	WP_033567083.1	hypothetical protein	-
L0F60_RS21850 (4455348)	4455348..4456220	-	873	WP_033567082.1	ParA family protein	-
L0F60_RS21855 (4456411)	4456411..4456488	-	78	Protein_4285	helix-turn-helix domain-containing protein	-
L0F60_RS21860 (4456579)	4456579..4456911	-	333	WP_001165471.1	MerR family transcriptional regulator	-
L0F60_RS21865 (4456983)	4456983..4457360	+	378	WP_000916345.1	EthD family reductase	-
L0F60_RS21870 (4458393)	4458393..4458467	+	75	Protein_4288	porin family protein	-
L0F60_RS21875 (4458570)	4458570..4459322	+	753	WP_000842434.1	non-specific acid phosphatase	-
L0F60_RS21880 (4459570)	4459570..4460061	-	492	WP_000626099.1	GNAT family N-acetyltransferase	Toxin
L0F60_RS21885 (4460058)	4460058..4460351	-	294	WP_001110452.1	DUF1778 domain-containing protein	Antitoxin
L0F60_RS21890 (4460668)	4460668..4460889	+	222	WP_001576552.1	hypothetical protein	-
L0F60_RS21895 (4461154)	4461154..4462029	+	876	WP_000921674.1	AraC family transcriptional regulator	-
L0F60_RS21900 (4462026)	4462026..4462313	+	288	WP_001269916.1	transcriptional regulator RtsB	-
L0F60_RS21905 (4462336)	4462336..4462551	+	216	WP_001595136.1	hypothetical protein	-
L0F60_RS21910 (4462559)	4462559..4462828	+	270	WP_010989096.1	hypothetical protein	-
L0F60_RS21915 (4463122)	4463122..4464027	-	906	WP_001268200.1	YjiK family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (85-145)

Antitoxin

• Vibrio phage ICP1, Orf50 (14-88)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 17646.39 Da
• Isoelectric Point: 6.8437

>T231034 WP_000626099.1 NZ_CP090529:c4460061-4459570 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Nucleotide

• Length: 492 bp

>T231034 NZ_CP125897:c2122291-2121929 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10977.61 Da
• Isoelectric Point: 8.6141

>AT231034 WP_001110452.1 NZ_CP090529:c4460351-4460058 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Nucleotide

• Length: 294 bp

>AT231034 NZ_CP125897:c2122458-2122288 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Toxin

• PDB: 7AK7

Antitoxin

• AlphaFold DB: A0A5I1DGA4