Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4249492..4250008 Replicon chromosome
Accession NZ_CP090529
Organism Salmonella enterica strain 2008079-SE

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag L0F60_RS20775 Protein ID WP_000220578.1
Coordinates 4249492..4249776 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag L0F60_RS20780 Protein ID WP_000212724.1
Coordinates 4249766..4250008 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F60_RS20760 (4244704) 4244704..4246356 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
L0F60_RS20765 (4246765) 4246765..4248903 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
L0F60_RS20770 (4249024) 4249024..4249488 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L0F60_RS20775 (4249492) 4249492..4249776 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0F60_RS20780 (4249766) 4249766..4250008 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L0F60_RS20785 (4250086) 4250086..4251999 - 1914 WP_001212137.1 BglG family transcription antiterminator -
L0F60_RS20790 (4252016) 4252016..4252756 - 741 WP_000779263.1 KDGP aldolase family protein -
L0F60_RS20795 (4252753) 4252753..4253871 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
L0F60_RS20800 (4253855) 4253855..4254988 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T231033 WP_000220578.1 NZ_CP090529:c4249776-4249492 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T231033 NZ_CP125897:c2022963-2022787 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT231033 WP_000212724.1 NZ_CP090529:c4250008-4249766 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT231033 NZ_CP125897:2022656-2022797 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References