Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3407286..3407917 Replicon chromosome
Accession NC_011283
Organism Klebsiella pneumoniae 342

Toxin (Protein)


Gene name hicA Uniprot ID A0A1Q8YTV3
Locus tag KPK_RS16030 Protein ID WP_012542177.1
Coordinates 3407741..3407917 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2X1QFN9
Locus tag KPK_RS16025 Protein ID WP_012542176.1
Coordinates 3407286..3407693 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPK_RS15990 3402791..3403222 - 432 WP_012542169.1 hypothetical protein -
KPK_RS29000 3403222..3403542 - 321 WP_012542170.1 hypothetical protein -
KPK_RS29005 3403494..3403856 - 363 WP_012542171.1 HNH endonuclease -
KPK_RS16005 3404184..3404381 + 198 WP_032414050.1 hypothetical protein -
KPK_RS31245 3404365..3404514 - 150 WP_181159912.1 hypothetical protein -
KPK_RS16010 3405457..3405807 - 351 WP_012542173.1 hypothetical protein -
KPK_RS16015 3405804..3406301 - 498 WP_032439908.1 lysozyme -
KPK_RS16020 3406279..3406548 - 270 WP_023289178.1 hypothetical protein -
KPK_RS16025 3407286..3407693 - 408 WP_012542176.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KPK_RS16030 3407741..3407917 - 177 WP_012542177.1 type II toxin-antitoxin system HicA family toxin Toxin
KPK_RS16035 3408278..3409435 + 1158 WP_020803203.1 DUF262 domain-containing protein -
KPK_RS29010 3409437..3410126 + 690 WP_012542179.1 hypothetical protein -
KPK_RS29015 3410092..3411135 - 1044 WP_012542180.1 DNA cytosine methyltransferase -
KPK_RS16040 3411225..3411569 - 345 WP_012542181.1 antitermination protein -
KPK_RS16045 3411582..3412613 - 1032 WP_012542182.1 DUF968 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3392831..3425549 32718


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-61)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6632.83 Da        Isoelectric Point: 11.0174

>T23103 WP_012542177.1 NC_011283:c3407917-3407741 [Klebsiella variicola]
VKQSELRRWLAAQGAEFKDGTNHLKIYLNGKQTVMPRHPGKEIPEPLRKAILKQLGIK

Download         Length: 177 bp

>T23103 NC_011283:c3407917-3407741 [Klebsiella variicola]
GTGAAGCAAAGCGAGTTGAGGCGTTGGCTTGCAGCTCAAGGGGCAGAATTTAAAGATGGTACTAACCACTTGAAAATCTA
TCTCAACGGCAAGCAAACGGTAATGCCGAGACATCCGGGGAAGGAAATACCGGAACCGCTGAGGAAGGCAATTCTTAAGC
AACTCGGCATCAAATAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14977.99 Da        Isoelectric Point: 4.4277

>AT23103 WP_012542176.1 NC_011283:c3407693-3407286 [Klebsiella variicola]
MRYPVIFEHDETGWAVFFPDIPEAMTGGETREEALEMAQDALVTAFDFYFDDRREIPAPSAEGDAFVEVPASVAAKVLLL
NRLVSTNTSNADLARMINTRPQEVQRIVSLGHSTKIDTIQKALSALGQKMEIVVH

Download         Length: 408 bp

>AT23103 NC_011283:c3407693-3407286 [Klebsiella variicola]
ATGCGATACCCGGTAATTTTTGAGCATGACGAAACCGGCTGGGCGGTATTCTTTCCGGATATCCCAGAGGCAATGACGGG
AGGAGAGACCAGGGAGGAAGCGTTAGAAATGGCGCAAGATGCCCTGGTGACGGCGTTTGATTTTTACTTTGACGACCGCC
GGGAGATTCCCGCTCCATCAGCAGAAGGTGATGCGTTTGTTGAGGTTCCGGCCAGCGTGGCAGCTAAAGTATTGCTGTTA
AACCGTCTGGTCAGCACCAACACCAGCAATGCTGATCTCGCCCGCATGATTAACACGCGCCCACAGGAAGTACAGCGCAT
CGTGTCTCTTGGTCACAGCACCAAAATCGATACGATCCAAAAAGCGCTATCAGCGTTGGGGCAAAAGATGGAAATTGTCG
TCCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q8YTV3

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1QFN9

References