231028

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3534979..3535599 Replicon chromosome
Accession NZ_CP090529
Organism Salmonella enterica strain 2008079-SE

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag L0F60_RS17490 Protein ID WP_001280991.1
Coordinates 3535381..3535599 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag L0F60_RS17485 Protein ID WP_000344807.1
Coordinates 3534979..3535353 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F60_RS17475 (3530118) 3530118..3531311 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L0F60_RS17480 (3531334) 3531334..3534483 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
L0F60_RS17485 (3534979) 3534979..3535353 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
L0F60_RS17490 (3535381) 3535381..3535599 + 219 WP_001280991.1 HHA domain-containing protein Toxin
L0F60_RS17495 (3535778) 3535778..3536329 + 552 WP_001278792.1 maltose O-acetyltransferase -
L0F60_RS17500 (3536446) 3536446..3536916 + 471 WP_000136181.1 YlaC family protein -
L0F60_RS17505 (3536972) 3536972..3537112 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
L0F60_RS17510 (3537118) 3537118..3537378 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
L0F60_RS17515 (3537603) 3537603..3539153 + 1551 WP_000213139.1 EAL domain-containing protein -
L0F60_RS17525 (3539384) 3539384..3539773 + 390 WP_000961285.1 MGMT family protein -
L0F60_RS17530 (3539806) 3539806..3540375 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T231028 WP_001280991.1 NZ_CP090529:3535381-3535599 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T231028 NZ_CP125895:c2461945-2461679 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATGATCCTTATAAAATAACACAATCCTTTGAAAAACTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT231028 WP_000344807.1 NZ_CP090529:3534979-3535353 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT231028 NZ_CP125895:c2462202-2461945 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References