Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 870115..870775 Replicon chromosome
Accession NZ_CP090529
Organism Salmonella enterica strain 2008079-SE

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag L0F60_RS04220 Protein ID WP_000244756.1
Coordinates 870362..870775 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag L0F60_RS04215 Protein ID WP_000351186.1
Coordinates 870115..870381 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0F60_RS04195 (866043) 866043..867476 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
L0F60_RS04200 (867635) 867635..867946 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
L0F60_RS04205 (868110) 868110..868769 + 660 WP_000250289.1 hemolysin III family protein -
L0F60_RS04210 (868885) 868885..869865 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
L0F60_RS04215 (870115) 870115..870381 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
L0F60_RS04220 (870362) 870362..870775 + 414 WP_000244756.1 protein YgfX Toxin
L0F60_RS04225 (870828) 870828..871349 - 522 WP_001055885.1 flavodoxin FldB -
L0F60_RS04230 (871462) 871462..872358 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
L0F60_RS04235 (872382) 872382..873095 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L0F60_RS04240 (873101) 873101..874834 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T231016 WP_000244756.1 NZ_CP090529:870362-870775 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T231016 NZ_CP125879:c334605-334414 [Auritidibacter ignavus]
ATGAAAGAGCTCAGGCCCGGCTCGTCTGGCCGGTCCGAGTTGCGCGTTCTGTTCGCGTTCGATCCAGAGCGAGTGGCGAT
CATGCTGATCGCCGGAGATAAGATCGGCGATTGGAAACGCTGGTATAAGAAGCACATTTCGTTGGCCGACGACCTCTTCG
ACGAGCATCTGGCCCGACTGAGAAGAGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT231016 WP_000351186.1 NZ_CP090529:870115-870381 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT231016 NZ_CP125879:c334408-334103 [Auritidibacter ignavus]
ATGGCAAAGAACCTGAAGGATTTCGTCGCCGAGCATCCTGTTGACCGGGGACGGGTTGAGGTGCACAAGAAGCGGATGCT
TGCTGAGGTTCGCGCCTACCGTCTGCGAGAGCTACGGGAGCAGGCCGGACTGACGCAAGCGCAGCTGGCAGAGCGCATTG
GCGTCGGGCAGCGGCAGGTTTCGAAGATCGAGCAAGGCGACCTCGACAGCGCGAAGGTTGGCACCATCCGCAGTTACCTT
GAGGCCGTCGGTGGCGAACTCTCCCTTGAGTACGTGATGGGAGACCAGCGAATGCAGGTCGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References