Detailed information of TA system TA231009

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 4171000..4171544
• Replicon: chromosome
• Accession: NZ_CP090523
• Organism: Xanthomonas citri pv. glycines strain ICMP5732

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LMJ37_RS17960
• Protein ID: WP_005928957.1
• Coordinates: 4171245..4171544 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1D9ED60
• Locus tag: LMJ37_RS17955
• Protein ID: WP_016849693.1
• Coordinates: 4171000..4171257 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LMJ37_RS17940 (LMJ37_17940)	4166101..4167600	-	1500	WP_029827796.1	ribonuclease H-like domain-containing protein	-
LMJ37_RS17945 (LMJ37_17945)	4167597..4170092	-	2496	WP_016849694.1	DEAD/DEAH box helicase	-
LMJ37_RS17950 (LMJ37_17950)	4170270..4170932	+	663	WP_005912558.1	hemolysin III family protein	-
LMJ37_RS17955 (LMJ37_17955)	4171000..4171257	+	258	WP_016849693.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LMJ37_RS17960 (LMJ37_17960)	4171245..4171544	+	300	WP_005928957.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LMJ37_RS17970 (LMJ37_17970)	4171732..4172630	-	899	Protein_3512	SDR family NAD(P)-dependent oxidoreductase	-
LMJ37_RS17975 (LMJ37_17975)	4172689..4173426	-	738	WP_016849691.1	SDR family oxidoreductase	-
LMJ37_RS17980 (LMJ37_17980)	4173552..4174463	+	912	WP_016849690.1	LysR family transcriptional regulator	-
LMJ37_RS17985 (LMJ37_17985)	4174660..4175733	-	1074	WP_026006953.1	ATP-grasp fold amidoligase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11260.02 Da
• Isoelectric Point: 9.7235

>T231009 WP_005928957.1 NZ_CP090523:4171245-4171544 [Xanthomonas citri pv. glycines]
MAEIIWSVPALADLDAIADYIAIDNAPAAAALVKRVFAHVEQLIEHPDSGSRPQELKRSRYRQIVEPPCRVFYRVDGQRI
VVVHIMRSERALRGNRLSR

Nucleotide

• Length: 300 bp

>T231009 NZ_CP125856:995848-996150 [Vibrio parahaemolyticus]
ATGGCTGAAATAATCTGGACTGAGCCAGCGCTATCCGACCTCAATGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAACAATTGGTTCAAACGATCGTTTCTAAAGTCGAGCGCTTAGAGGCTTTCCCTGAATCGGGTCGCATTCCGC
CTGAATTAGAACATCTAAGCTATCGTGAAGTTGTAGTTAATCCGTGCCGCGTTTTCTATAAACAAGACGGCGACAAAGTA
TTTATTCTGTTTGTTATGCGTGCTGAGAGAGACTTGCGTAAGTTCCTATTGAGCAAGCAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9674.20 Da
• Isoelectric Point: 9.8271

>AT231009 WP_016849693.1 NZ_CP090523:4171000-4171257 [Xanthomonas citri pv. glycines]
MRTELVTTLKRQATELLAAAERDKEPILITQHGLPSAYLVDVASYERMQQRIALLEGIARGEMAVAEGRTLSHEQARQRM
ARWLK

Nucleotide

• Length: 258 bp

>AT231009 NZ_CP125856:995603-995860 [Vibrio parahaemolyticus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACAAAAATCCTTGCCGATCTCCACGACACTAAAGAACCAGT
GTTAATTACCGAACATGGCAAGCCATCGGCATATCTGGTTGATGTTGATGATTACGAGTTTATGCAAAATCGTTTGGCGA
TTCTGGAGGGGATTGCACGAGGTGAACGTGCATTAGCGGATGGTAAAGTGGTGAGTCACGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A1D9ED60