Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 4000130..4000797 Replicon chromosome
Accession NZ_CP090523
Organism Xanthomonas citri pv. glycines strain ICMP5732

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag LMJ37_RS17255 Protein ID WP_005916679.1
Coordinates 4000381..4000797 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag LMJ37_RS17250 Protein ID WP_005916676.1
Coordinates 4000130..4000384 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMJ37_RS17225 (LMJ37_17225) 3996302..3996445 + 144 WP_005916661.1 RNA 2'-phosphotransferase -
LMJ37_RS17230 (LMJ37_17230) 3996628..3997893 + 1266 WP_016849472.1 phospholipase D-like domain-containing protein -
LMJ37_RS17235 (LMJ37_17235) 3997919..3998446 - 528 WP_005916668.1 hypothetical protein -
LMJ37_RS17240 (LMJ37_17240) 3998685..3998891 + 207 WP_003489327.1 hypothetical protein -
LMJ37_RS17245 (LMJ37_17245) 3998878..3999984 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
LMJ37_RS17250 (LMJ37_17250) 4000130..4000384 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
LMJ37_RS17255 (LMJ37_17255) 4000381..4000797 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
LMJ37_RS17260 (LMJ37_17260) 4000919..4001191 - 273 WP_124632111.1 hypothetical protein -
LMJ37_RS17265 (LMJ37_17265) 4001204..4001464 - 261 WP_124632112.1 hypothetical protein -
LMJ37_RS17270 (LMJ37_17270) 4001721..4003340 + 1620 WP_016849230.1 alpha/beta hydrolase-fold protein -
LMJ37_RS17275 (LMJ37_17275) 4003444..4003842 - 399 WP_004429277.1 DUF2384 domain-containing protein -
LMJ37_RS17280 (LMJ37_17280) 4004158..4004589 + 432 WP_016849229.1 hypothetical protein -
LMJ37_RS17285 (LMJ37_17285) 4004618..4004848 - 231 WP_226690114.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T231008 WP_005916679.1 NZ_CP090523:4000381-4000797 [Xanthomonas citri pv. glycines]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T231008 NZ_CP125806:1959739-1960065 [Pasteurella multocida]
ATGGACAGAGTCCGATTTAATCTTACGGAAGATAGCTTCCAAGACAAGTATCTGTATGAGTATTTTTTATATGGAAGTAA
GCATAAAAATATTCCAAGTGATATAGAAAATACGCTAGCGCATAAATTAGATATGTTAGATAGCGCAAATACTTTGAATG
ATTTGCGAAGTCCACCAGGTAATAAATTGGAAAAATTGGAGCCTAAAACGAGTGGGCTATATTCTATCAGAGTGAATGTG
AAATATCGTTTAATATTTAAATATAAAGAAAGTAATTTTCCAAAAATAACAGAGTTGAGATTAGATAAACATCAATATAG
ATTATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT231008 WP_005916676.1 NZ_CP090523:4000130-4000384 [Xanthomonas citri pv. glycines]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT231008 NZ_CP125806:1960166-1960492 [Pasteurella multocida]
ATGAGTAGAGTACAAAGAAAGCCATCAACAGTGGGTGATATTTTATTAGATGAATATTTAGTTCCACTAAATTTGAAAAT
TGCAGATTTAGCTACAATGTTAGATGTTCATCGTAATACAGCAAGTGCACTCGTTAATAATAATACTAAATTGTCTTTAG
AAATGGCACTGAAACTAGCAAAACTATTTAATACAAGTCCTGAGTTTTGGTTAAATTTACAAATGAAATTAGACTTATGG
GAAATTGAAAACAATGCTAGGTTTCAAGAAAGTTTAAAGAAAATTTTGTCTATTGATCAGCATAACCTGTTAGAAAAAAT
CGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References