Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1372969..1373638 Replicon chromosome
Accession NZ_CP090522
Organism Streptococcus parasuis strain SS17

Toxin (Protein)


Gene name hicA Uniprot ID G7SGM1
Locus tag LOD78_RS06965 Protein ID WP_014637653.1
Coordinates 1373456..1373638 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOD78_RS06960 Protein ID WP_160863757.1
Coordinates 1372969..1373418 (-) Length 150 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOD78_RS06945 (LOD78_06940) 1368100..1370562 - 2463 WP_274512984.1 heavy metal translocating P-type ATPase -
LOD78_RS06950 (LOD78_06945) 1370657..1371514 - 858 WP_274505209.1 SAM-dependent methyltransferase TehB -
LOD78_RS06955 (LOD78_06950) 1371767..1372810 + 1044 WP_274505211.1 alcohol dehydrogenase catalytic domain-containing protein -
LOD78_RS06960 (LOD78_06955) 1372969..1373418 - 450 WP_160863757.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOD78_RS06965 (LOD78_06960) 1373456..1373638 - 183 WP_014637653.1 type II toxin-antitoxin system HicA family toxin Toxin
LOD78_RS06970 (LOD78_06965) 1374016..1374483 - 468 WP_274505213.1 SsrA-binding protein SmpB -
LOD78_RS06975 (LOD78_06970) 1374486..1376855 - 2370 WP_274505214.1 ribonuclease R -
LOD78_RS06980 (LOD78_06975) 1377119..1377352 - 234 WP_171989834.1 preprotein translocase subunit SecG -
LOD78_RS06985 (LOD78_06980) 1377399..1377548 - 150 WP_012775228.1 50S ribosomal protein L33 -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-59)

Antitoxin

(17-113)


Sequences


Toxin        


Download         Length: 61 a.a.        Molecular weight: 6653.87 Da        Isoelectric Point: 10.8207

>T231006 WP_014637653.1 NZ_CP090522:c1373638-1373456 [Streptococcus parasuis]
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL

Download         Length: 183 bp

>T231006 NZ_CP125806:1570096-1570410 [Pasteurella multocida]
ATGCTCGATATAATTGAAACAACAGTATTTAATAAATGGCTTAAAGAGCTAAAGGATTTGTCGGCTAAAGCGGCTATTCT
TGCACGTATTAGTCGCGCTAAAAGTGGTAATTTTGGTGACCATAAATCAGTTGGTGATGGTTTGTATGAAATGCGAATAA
TGAAAGGAGCTGGTTATAGGGTTTATTATGCACAATACAAAGATGTAACCTATTTGCTAATTTGTGGCGGTGATAAATCT
ACTCAGAAAGCAGATATCGCTAAAGCAAAAGCATTATGGGAAGAGATTAAGCAGAAAGAGGAGATAAATGTATGA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16639.64 Da        Isoelectric Point: 3.9790

>AT231006 WP_160863757.1 NZ_CP090522:c1373418-1372969 [Streptococcus parasuis]
MLVTYPALFYFDDTDGANAPYFVTFPDFEHSATQGEDMADAMAMASDWLGMNLADYIENGRDIPTPSSINTLSLVDNNPF
RDEDFEMVYDSSKSFISMVMVDVAKYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Download         Length: 450 bp

>AT231006 NZ_CP125806:1570407-1570697 [Pasteurella multocida]
ATGAGTAAAAAAGTAGAATTAAAACCATTTGATATTGCTGAATACCTAGATAGTGAAGAAATGATTGCGGCATATTTAAG
TGAAATTTTAGAAACAGGTGACACTAATGAATTTATTTCTGCGCTAGGTGATGTCGCAAGAGCGAGAGGAATGACGGAGT
TAGCGGCAAAAACAGGATTAGGAAGAGAAAGTCTCTATAAAACATTATCACACGGAAGTAAGCCGCGTTTTGATACTATA
ATGAAAATTACGCAAGCACTAGGTATTAAACTTGTCCCAACGCATATCTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G7SGM1


Antitoxin

Source ID Structure

References