Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 1372969..1373638 | Replicon | chromosome |
Accession | NZ_CP090522 | ||
Organism | Streptococcus parasuis strain SS17 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | G7SGM1 |
Locus tag | LOD78_RS06965 | Protein ID | WP_014637653.1 |
Coordinates | 1373456..1373638 (-) | Length | 61 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | - |
Locus tag | LOD78_RS06960 | Protein ID | WP_160863757.1 |
Coordinates | 1372969..1373418 (-) | Length | 150 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LOD78_RS06945 (LOD78_06940) | 1368100..1370562 | - | 2463 | WP_274512984.1 | heavy metal translocating P-type ATPase | - |
LOD78_RS06950 (LOD78_06945) | 1370657..1371514 | - | 858 | WP_274505209.1 | SAM-dependent methyltransferase TehB | - |
LOD78_RS06955 (LOD78_06950) | 1371767..1372810 | + | 1044 | WP_274505211.1 | alcohol dehydrogenase catalytic domain-containing protein | - |
LOD78_RS06960 (LOD78_06955) | 1372969..1373418 | - | 450 | WP_160863757.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
LOD78_RS06965 (LOD78_06960) | 1373456..1373638 | - | 183 | WP_014637653.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
LOD78_RS06970 (LOD78_06965) | 1374016..1374483 | - | 468 | WP_274505213.1 | SsrA-binding protein SmpB | - |
LOD78_RS06975 (LOD78_06970) | 1374486..1376855 | - | 2370 | WP_274505214.1 | ribonuclease R | - |
LOD78_RS06980 (LOD78_06975) | 1377119..1377352 | - | 234 | WP_171989834.1 | preprotein translocase subunit SecG | - |
LOD78_RS06985 (LOD78_06980) | 1377399..1377548 | - | 150 | WP_012775228.1 | 50S ribosomal protein L33 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6653.87 Da Isoelectric Point: 10.8207
>T231006 WP_014637653.1 NZ_CP090522:c1373638-1373456 [Streptococcus parasuis]
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL
Download Length: 183 bp
>T231006 NZ_CP125806:1570096-1570410 [Pasteurella multocida]
ATGCTCGATATAATTGAAACAACAGTATTTAATAAATGGCTTAAAGAGCTAAAGGATTTGTCGGCTAAAGCGGCTATTCT
TGCACGTATTAGTCGCGCTAAAAGTGGTAATTTTGGTGACCATAAATCAGTTGGTGATGGTTTGTATGAAATGCGAATAA
TGAAAGGAGCTGGTTATAGGGTTTATTATGCACAATACAAAGATGTAACCTATTTGCTAATTTGTGGCGGTGATAAATCT
ACTCAGAAAGCAGATATCGCTAAAGCAAAAGCATTATGGGAAGAGATTAAGCAGAAAGAGGAGATAAATGTATGA
ATGCTCGATATAATTGAAACAACAGTATTTAATAAATGGCTTAAAGAGCTAAAGGATTTGTCGGCTAAAGCGGCTATTCT
TGCACGTATTAGTCGCGCTAAAAGTGGTAATTTTGGTGACCATAAATCAGTTGGTGATGGTTTGTATGAAATGCGAATAA
TGAAAGGAGCTGGTTATAGGGTTTATTATGCACAATACAAAGATGTAACCTATTTGCTAATTTGTGGCGGTGATAAATCT
ACTCAGAAAGCAGATATCGCTAAAGCAAAAGCATTATGGGAAGAGATTAAGCAGAAAGAGGAGATAAATGTATGA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16639.64 Da Isoelectric Point: 3.9790
>AT231006 WP_160863757.1 NZ_CP090522:c1373418-1372969 [Streptococcus parasuis]
MLVTYPALFYFDDTDGANAPYFVTFPDFEHSATQGEDMADAMAMASDWLGMNLADYIENGRDIPTPSSINTLSLVDNNPF
RDEDFEMVYDSSKSFISMVMVDVAKYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA
MLVTYPALFYFDDTDGANAPYFVTFPDFEHSATQGEDMADAMAMASDWLGMNLADYIENGRDIPTPSSINTLSLVDNNPF
RDEDFEMVYDSSKSFISMVMVDVAKYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA
Download Length: 450 bp
>AT231006 NZ_CP125806:1570407-1570697 [Pasteurella multocida]
ATGAGTAAAAAAGTAGAATTAAAACCATTTGATATTGCTGAATACCTAGATAGTGAAGAAATGATTGCGGCATATTTAAG
TGAAATTTTAGAAACAGGTGACACTAATGAATTTATTTCTGCGCTAGGTGATGTCGCAAGAGCGAGAGGAATGACGGAGT
TAGCGGCAAAAACAGGATTAGGAAGAGAAAGTCTCTATAAAACATTATCACACGGAAGTAAGCCGCGTTTTGATACTATA
ATGAAAATTACGCAAGCACTAGGTATTAAACTTGTCCCAACGCATATCTAA
ATGAGTAAAAAAGTAGAATTAAAACCATTTGATATTGCTGAATACCTAGATAGTGAAGAAATGATTGCGGCATATTTAAG
TGAAATTTTAGAAACAGGTGACACTAATGAATTTATTTCTGCGCTAGGTGATGTCGCAAGAGCGAGAGGAATGACGGAGT
TAGCGGCAAAAACAGGATTAGGAAGAGAAAGTCTCTATAAAACATTATCACACGGAAGTAAGCCGCGTTTTGATACTATA
ATGAAAATTACGCAAGCACTAGGTATTAAACTTGTCCCAACGCATATCTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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