Detailed information of TA system TA231004

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1332991..1333616
• Replicon: chromosome
• Accession: NZ_CP090522
• Organism: Streptococcus parasuis strain SS17

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LOD78_RS06770
• Protein ID: WP_171989763.1
• Coordinates: 1332991..1333329 (-)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: LOD78_RS06775
• Protein ID: WP_130554939.1
• Coordinates: 1333329..1333616 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOD78_RS06740 (LOD78_06735)	1328129..1329040	-	912	WP_274512950.1	DNA-binding protein WhiA	-
LOD78_RS06745 (LOD78_06740)	1329037..1330011	-	975	WP_274512952.1	YvcK family protein	-
LOD78_RS06750 (LOD78_06745)	1330008..1330895	-	888	WP_274512954.1	RNase adapter RapZ	-
LOD78_RS06755 (LOD78_06750)	1330918..1331298	-	381	WP_274512955.1	RidA family protein	-
LOD78_RS06760 (LOD78_06755)	1331348..1332667	-	1320	WP_274512957.1	MATE family efflux transporter	-
LOD78_RS06765 (LOD78_06760)	1332807..1333010	-	204	WP_171989762.1	LPXTG cell wall anchor domain-containing protein	-
LOD78_RS06770 (LOD78_06765)	1332991..1333329	-	339	WP_171989763.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LOD78_RS06775 (LOD78_06770)	1333329..1333616	-	288	WP_130554939.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LOD78_RS06780 (LOD78_06775)	1333770..1334039	-	270	WP_105127516.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LOD78_RS06785 (LOD78_06780)	1334029..1334256	-	228	WP_130554954.1	DUF6290 family protein	-
LOD78_RS06790 (LOD78_06785)	1334594..1335940	-	1347	WP_216806577.1	asparagine--tRNA ligase	-
LOD78_RS06795 (LOD78_06790)	1335955..1337136	-	1182	WP_274512958.1	pyridoxal phosphate-dependent aminotransferase	-
LOD78_RS06800 (LOD78_06795)	1337133..1337630	-	498	WP_172035833.1	DUF5590 domain-containing protein	-
LOD78_RS06805 (LOD78_06800)	1337777..1338217	+	441	WP_130554934.1	MarR family winged helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-106)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (10-81)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12914.84 Da
• Isoelectric Point: 5.9262

>T231004 WP_171989763.1 NZ_CP090522:c1333329-1332991 [Streptococcus parasuis]
MEKYRVIISPKLIEQIKSIRDYVANVKLSPETAERLVTAIFDEIESLELFPERGFDADEKIGVKIDKNGRSSRGITIQNG
KYIVIYTVNQEEHLVEVAFLFSSKTDYAKLFR

Nucleotide

• Length: 339 bp

>T231004 NZ_CP125806:c968293-968000 [Pasteurella multocida]
ATGAGTAAGAAAAAAATAAAATTAAAACTGTTTGATATTGCTGAACATCTAGACAGTGAAGAAATGATTGCGGCATATTT
AAGTGAAGTTTTAGAAACATGTGATACTAATGAATTTATTTCCGCTTTAGCTGATGTTGTAAGAGCAAAAGGAATGACGG
AGTTAGCAGCAAAAACAGGGTTAAGAAGAGAAAGCCTCTATAAAACATTATCATACGGTAGCAAGCCACGTTTTGATACG
ATAATGAAAATTACGCATTCATTAGGTATTAAACTTGTCCCAACGCACATCTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10811.34 Da
• Isoelectric Point: 4.7494

>AT231004 WP_130554939.1 NZ_CP090522:c1333616-1333329 [Streptococcus parasuis]
MPTVIRDKQINFKVNSEYFELAKVVFQENGLDITSAFNEFVQEVAISKTLPFKTVEEKEREKLIARLQEEVSTSYEALKA
DKGLSVEEARKAVLG

Nucleotide

• Length: 288 bp

>AT231004 NZ_CP125806:c968574-968290 [Pasteurella multocida]
GTGGGTCGGTTAAGGGAGGTAAAAAATTTATCCGCCAAAGCCGCTGTTCTTGCTCGTATTAACAGAGTAATGAATGGTAA
TTTGGGCGATCATAAATCGATTGGAAATGGATTGTATGAGATGAGAATTATAAAAGGTTCGGGTTATAGAGTTTACTATG
GACAATATAGAGAAGTAACTTATTTATTAATTTGTGGTGGCGATAAATCAACACAGAAATCAGACATTGTTAAAGCGAGA
GAGTTGTGGAAAGAAATAAAGCAACAAGAGGAAGTAAAAGTATGA