Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 984241..984733 Replicon chromosome
Accession NZ_CP090522
Organism Streptococcus parasuis strain SS17

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LOD78_RS05010 Protein ID WP_172034832.1
Coordinates 984241..984498 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LOD78_RS05015 Protein ID WP_171988478.1
Coordinates 984482..984733 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOD78_RS04990 (LOD78_04985) 979559..980629 + 1071 WP_274505936.1 tyrosine recombinase XerS -
LOD78_RS04995 (LOD78_04990) 980907..982415 - 1509 WP_274504992.1 phosphomannomutase/phosphoglucomutase -
LOD78_RS05000 (LOD78_04995) 982596..983537 - 942 WP_274504993.1 sensor histidine kinase -
LOD78_RS05005 (LOD78_05000) 983534..984202 - 669 WP_274504994.1 response regulator transcription factor -
LOD78_RS05010 (LOD78_05005) 984241..984498 - 258 WP_172034832.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOD78_RS05015 (LOD78_05010) 984482..984733 - 252 WP_171988478.1 DUF6290 family protein Antitoxin
LOD78_RS05020 (LOD78_05015) 984968..986938 - 1971 WP_274504995.1 ABC transporter permease -
LOD78_RS05025 (LOD78_05020) 986939..987691 - 753 WP_274513076.1 ABC transporter ATP-binding protein -
LOD78_RS05030 (LOD78_05025) 987700..988089 - 390 WP_274513077.1 NisI/SpaI family lantibiotic immunity lipoprotein -
LOD78_RS05035 (LOD78_05030) 988102..988242 - 141 WP_171988482.1 hypothetical protein -
LOD78_RS05040 (LOD78_05035) 988381..989547 - 1167 WP_274513078.1 ATP-grasp domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9928.52 Da        Isoelectric Point: 10.8924

>T231003 WP_172034832.1 NZ_CP090522:c984498-984241 [Streptococcus parasuis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKVTVTSLKM
RNGSI

Download         Length: 258 bp

>T231003 NZ_CP125806:54385-54681 [Pasteurella multocida]
ATGGAACAATTAAAAGATTTTGATATAGCAGAACATTTAACAACAGAAGAAGAAATCCGACTTTATCTTAATGAAATTTT
ACAAGAAGATAATATTGAATTGATTCTCTCCGCACTTGGCGATATTGCAAGGGCTAGAAATATAAGCCAAATCTCTCGAG
AAACTGGAATTAGTAGAGAAGGGCTTTATAAGGCATTATCTGGAAAAGGAAATCCGACCTTTGCAACAGTCCTTAAAGTG
ATGAAGGCTTTGAATTTACAGTTTGAAGTTAAAGTAAATAACGTTATTCATGCTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9351.58 Da        Isoelectric Point: 3.7128

>AT231003 WP_171988478.1 NZ_CP090522:c984733-984482 [Streptococcus parasuis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALAEYQEDLANGIEPISWEEMLEELGLTNE
DLL

Download         Length: 252 bp

>AT231003 NZ_CP125806:54084-54383 [Pasteurella multocida]
ATGACAATTCGAATTAAAACAACTGAGCGCTTTGATTCTTGGCTGAGAAAGCTTAAAAATCCTCGCGCAAAGATGAAAAT
TAATGCGCGTATTAAGCGGTTACAATTCGGAAATTTTGGTGACTTAAAAACTGTTAATGATGGCATTTTTGAAATGCGTA
TAGATGAAGGGCAGGGGTATAGAATTTATTTAAAAAATAACAATAGTGTGGTGGTTATATTGTTGTGTGGTGGTGATAAA
TCAACACAAAACAAAGATATTAAATTAGCAAAACAAATTGCAGAAGAATTGGGGGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References