Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 160212..160606 Replicon chromosome
Accession NZ_CP090522
Organism Streptococcus parasuis strain SS17

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag LOD78_RS00850 Protein ID WP_239604456.1
Coordinates 160436..160606 (+) Length 57 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag LOD78_RS00845 Protein ID WP_274505528.1
Coordinates 160212..160340 (+) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOD78_RS00810 (LOD78_00800) 155269..155628 + 360 WP_174846592.1 ribonuclease P protein component -
LOD78_RS00815 (LOD78_00805) 155612..156424 + 813 WP_274505527.1 YidC/Oxa1 family membrane protein insertase -
LOD78_RS00820 (LOD78_00810) 156443..157447 + 1005 WP_171988964.1 RNA-binding cell elongation regulator Jag/EloR -
LOD78_RS00825 (LOD78_00815) 157669..157806 + 138 WP_049618373.1 50S ribosomal protein L34 -
LOD78_RS00830 (LOD78_00820) 157856..158737 - 882 WP_174846590.1 diacylglycerol kinase family lipid kinase -
LOD78_RS00835 (LOD78_00825) 158887..159669 + 783 WP_171988962.1 TatD family hydrolase -
LOD78_RS00840 (LOD78_00830) 159653..160219 + 567 WP_171989046.1 ribonuclease M5 -
LOD78_RS00845 160212..160340 + 129 WP_274505528.1 hypothetical protein Antitoxin
LOD78_RS00850 (LOD78_00835) 160436..160606 + 171 WP_239604456.1 hypothetical protein Toxin
LOD78_RS00855 (LOD78_00840) 160613..160865 + 253 Protein_147 NUDIX domain-containing protein -
LOD78_RS00860 (LOD78_00845) 160904..161776 + 873 WP_274505529.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
LOD78_RS00865 (LOD78_00850) 163021..163761 + 741 WP_174846588.1 amino acid transporter -
LOD78_RS00870 (LOD78_00855) 163771..164349 + 579 WP_239604458.1 CPBP family intramembrane metalloprotease -
LOD78_RS00875 (LOD78_00860) 164361..164789 + 429 WP_171988959.1 Msa family membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 159653..170552 10899


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(45-88)


Sequences

Toxin        


Download         Length: 57 a.a.        Molecular weight: 6555.70 Da        Isoelectric Point: 10.3173

>T231002 WP_239604456.1 NZ_CP090522:160436-160606 [Streptococcus parasuis]
MSFNADNRFGKQIDPLHLTRGYVIGKDYIALYRVVKNELRVVHLFATKSDYVKLLK

Download         Length: 171 bp

>T231002 NZ_CP125806:54084-54383 [Pasteurella multocida]
ATGACAATTCGAATTAAAACAACTGAGCGCTTTGATTCTTGGCTGAGAAAGCTTAAAAATCCTCGCGCAAAGATGAAAAT
TAATGCGCGTATTAAGCGGTTACAATTCGGAAATTTTGGTGACTTAAAAACTGTTAATGATGGCATTTTTGAAATGCGTA
TAGATGAAGGGCAGGGGTATAGAATTTATTTAAAAAATAACAATAGTGTGGTGGTTATATTGTTGTGTGGTGGTGATAAA
TCAACACAAAACAAAGATATTAAATTAGCAAAACAAATTGCAGAAGAATTGGGGGTATGA

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 4754.44 Da        Isoelectric Point: 3.6534

>AT231002 WP_274505528.1 NZ_CP090522:160212-160340 [Streptococcus parasuis]
MSELETGKEVFAMNELDLTASFNLILQNIAVKNELLILTEEE

Download         Length: 129 bp

>AT231002 NZ_CP125806:54385-54681 [Pasteurella multocida]
ATGGAACAATTAAAAGATTTTGATATAGCAGAACATTTAACAACAGAAGAAGAAATCCGACTTTATCTTAATGAAATTTT
ACAAGAAGATAATATTGAATTGATTCTCTCCGCACTTGGCGATATTGCAAGGGCTAGAAATATAAGCCAAATCTCTCGAG
AAACTGGAATTAGTAGAGAAGGGCTTTATAAGGCATTATCTGGAAAAGGAAATCCGACCTTTGCAACAGTCCTTAAAGTG
ATGAAGGCTTTGAATTTACAGTTTGAAGTTAAAGTAAATAACGTTATTCATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References