Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pasABC/RelE-HTH |
| Location | 1400124..1400601 | Replicon | chromosome |
| Accession | NZ_CP090518 | ||
| Organism | Xylella fastidiosa subsp. fastidiosa strain Stag's Leap | ||
Toxin (Protein)
| Gene name | pasB | Uniprot ID | Q87CA4 |
| Locus tag | LZ752_RS06390 | Protein ID | WP_011097988.1 |
| Coordinates | 1400335..1400601 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | pasA | Uniprot ID | A0A7G7TPD2 |
| Locus tag | LZ752_RS06385 | Protein ID | WP_004091377.1 |
| Coordinates | 1400124..1400351 (+) | Length | 76 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZ752_RS06340 (LZ752_06340) | 1395252..1396397 | - | 1146 | WP_061278117.1 | baseplate J/gp47 family protein | - |
| LZ752_RS06345 (LZ752_06345) | 1396496..1396792 | + | 297 | WP_004089252.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LZ752_RS06350 (LZ752_06350) | 1396796..1397101 | + | 306 | WP_004089254.1 | putative addiction module antidote protein | - |
| LZ752_RS06355 (LZ752_06355) | 1397112..1397465 | - | 354 | WP_011097986.1 | hypothetical protein | - |
| LZ752_RS06360 (LZ752_06360) | 1397462..1398103 | - | 642 | WP_004090764.1 | Gp138 family membrane-puncturing spike protein | - |
| LZ752_RS06365 (LZ752_06365) | 1398100..1398309 | - | 210 | WP_234552888.1 | hypothetical protein | - |
| LZ752_RS06370 (LZ752_06370) | 1398306..1398929 | - | 624 | WP_234552889.1 | hypothetical protein | - |
| LZ752_RS06375 (LZ752_06375) | 1398926..1399243 | - | 318 | WP_011097873.1 | hypothetical protein | - |
| LZ752_RS06380 (LZ752_06380) | 1399243..1400013 | - | 771 | WP_004090769.1 | hypothetical protein | - |
| LZ752_RS06385 (LZ752_06385) | 1400124..1400351 | + | 228 | WP_004091377.1 | DUF6290 family protein | Antitoxin |
| LZ752_RS06390 (LZ752_06390) | 1400335..1400601 | + | 267 | WP_011097988.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LZ752_RS06395 (LZ752_06395) | 1400612..1402060 | - | 1449 | WP_234552890.1 | hypothetical protein | - |
| LZ752_RS06400 (LZ752_06400) | 1401985..1402620 | - | 636 | WP_234552891.1 | hypothetical protein | - |
| LZ752_RS06405 (LZ752_06405) | 1402647..1403069 | - | 423 | WP_011097875.1 | putative phage tail assembly chaperone | - |
| LZ752_RS06410 (LZ752_06410) | 1403066..1403503 | - | 438 | WP_011097876.1 | DUF3277 family protein | - |
| LZ752_RS06415 (LZ752_06415) | 1403513..1403746 | - | 234 | WP_061278122.1 | DUF3383 family protein | - |
| LZ752_RS06420 (LZ752_06420) | 1403763..1404641 | - | 879 | WP_012382645.1 | RNA-guided endonuclease TnpB family protein | - |
| LZ752_RS06425 (LZ752_06425) | 1404807..1404968 | - | 162 | WP_014607806.1 | helix-turn-helix domain-containing protein | - |
| LZ752_RS06430 (LZ752_06430) | 1404962..1405567 | - | 606 | Protein_1247 | IS607 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1393447..1436358 | 42911 | |
| - | flank | IS/Tn | - | - | 1404962..1405183 | 221 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10163.79 Da Isoelectric Point: 10.6086
>T230999 WP_011097988.1 NZ_CP090518:1400335-1400601 [Xylella fastidiosa subsp. fastidiosa]
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSSGKALTGPLGGFWRYRVGDFRVVCAIQDSVLRVLVVRV
GHRGEIYR
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSSGKALTGPLGGFWRYRVGDFRVVCAIQDSVLRVLVVRV
GHRGEIYR
Download Length: 267 bp
>T230999 NZ_CP125805:c312921-312517 [Mannheimia bovis]
ATGATCTATATGCTTGATACCAATATTTTGATTTATTTAATGAAAAATCGACCGCTTGCAGTGGCAGAACGTGTGGCACA
ACTTACGCCAAGTGATCAATTAGTTATGAGCTTTATTACCTATGCTGAATTGCTCAAAGGAGCAAATGGCAGTGCTAATC
CGGAAAAAGCCTTAGCGAATATCGAAAAGTTGAAACAACGTATTTCAGTTGTTTACCCAAATGAAAAAATCTGTGAATTT
TATGGTGTTTGGGCAAATAAATTGAAGTTACAAGGCAAGCCCATTGGTGGAAATGATTTATGGATTGCTTGTTACGCTTT
AGCTTGTAATGCGATATTAGTAACGCATAATGTCAAAGAGTTCGAGCGAATTGAAGCATTAAATTGGCAAGATTGGACGT
GTTAA
ATGATCTATATGCTTGATACCAATATTTTGATTTATTTAATGAAAAATCGACCGCTTGCAGTGGCAGAACGTGTGGCACA
ACTTACGCCAAGTGATCAATTAGTTATGAGCTTTATTACCTATGCTGAATTGCTCAAAGGAGCAAATGGCAGTGCTAATC
CGGAAAAAGCCTTAGCGAATATCGAAAAGTTGAAACAACGTATTTCAGTTGTTTACCCAAATGAAAAAATCTGTGAATTT
TATGGTGTTTGGGCAAATAAATTGAAGTTACAAGGCAAGCCCATTGGTGGAAATGATTTATGGATTGCTTGTTACGCTTT
AGCTTGTAATGCGATATTAGTAACGCATAATGTCAAAGAGTTCGAGCGAATTGAAGCATTAAATTGGCAAGATTGGACGT
GTTAA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8615.63 Da Isoelectric Point: 5.0958
>AT230999 WP_004091377.1 NZ_CP090518:1400124-1400351 [Xylella fastidiosa subsp. fastidiosa]
MATSIRLSPEMEQRLNSLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLGLDD
MATSIRLSPEMEQRLNSLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLGLDD
Download Length: 228 bp
>AT230999 NZ_CP125805:c313157-312918 [Mannheimia bovis]
ATGCGAACAAAAGTCTTCCAAAGTGGTAATAGCCAAGCGGTGAGGATTCCGTTTGATTTCCGTTTTGACGTAGATACCGT
AGAGATTTTACAAGGGCAGAATGGCGATGTTATTTTGCGTCCGGTGAAACCTCAAGCCGATATGGAATTTCTGGCTTTAT
TTTCCGATTTTGATGATGATTTTATTCAGGCATTGGAAGATAGAGATACATCGCCACCACAAGAGCGAGATACTTTATGA
ATGCGAACAAAAGTCTTCCAAAGTGGTAATAGCCAAGCGGTGAGGATTCCGTTTGATTTCCGTTTTGACGTAGATACCGT
AGAGATTTTACAAGGGCAGAATGGCGATGTTATTTTGCGTCCGGTGAAACCTCAAGCCGATATGGAATTTCTGGCTTTAT
TTTCCGATTTTGATGATGATTTTATTCAGGCATTGGAAGATAGAGATACATCGCCACCACAAGAGCGAGATACTTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A060HDH1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7G7TPD2 |