Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PumA-relB/COG3657-DUF971 |
| Location | 1396496..1397101 | Replicon | chromosome |
| Accession | NZ_CP090518 | ||
| Organism | Xylella fastidiosa subsp. fastidiosa strain Stag's Leap | ||
Toxin (Protein)
| Gene name | PumA | Uniprot ID | B2I5N3 |
| Locus tag | LZ752_RS06345 | Protein ID | WP_004089252.1 |
| Coordinates | 1396496..1396792 (+) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | LZ752_RS06350 | Protein ID | WP_004089254.1 |
| Coordinates | 1396796..1397101 (+) | Length | 102 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZ752_RS06320 (LZ752_06320) | 1391661..1392638 | + | 978 | WP_004087353.1 | hypothetical protein | - |
| LZ752_RS06325 (LZ752_06325) | 1392897..1393343 | + | 447 | WP_004087355.1 | hypothetical protein | - |
| LZ752_RS06330 (LZ752_06330) | 1393447..1394691 | - | 1245 | WP_011097983.1 | tail fiber protein | - |
| LZ752_RS06335 (LZ752_06335) | 1394695..1395255 | - | 561 | WP_004084996.1 | DUF2612 domain-containing protein | - |
| LZ752_RS06340 (LZ752_06340) | 1395252..1396397 | - | 1146 | WP_061278117.1 | baseplate J/gp47 family protein | - |
| LZ752_RS06345 (LZ752_06345) | 1396496..1396792 | + | 297 | WP_004089252.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LZ752_RS06350 (LZ752_06350) | 1396796..1397101 | + | 306 | WP_004089254.1 | putative addiction module antidote protein | Antitoxin |
| LZ752_RS06355 (LZ752_06355) | 1397112..1397465 | - | 354 | WP_011097986.1 | hypothetical protein | - |
| LZ752_RS06360 (LZ752_06360) | 1397462..1398103 | - | 642 | WP_004090764.1 | Gp138 family membrane-puncturing spike protein | - |
| LZ752_RS06365 (LZ752_06365) | 1398100..1398309 | - | 210 | WP_234552888.1 | hypothetical protein | - |
| LZ752_RS06370 (LZ752_06370) | 1398306..1398929 | - | 624 | WP_234552889.1 | hypothetical protein | - |
| LZ752_RS06375 (LZ752_06375) | 1398926..1399243 | - | 318 | WP_011097873.1 | hypothetical protein | - |
| LZ752_RS06380 (LZ752_06380) | 1399243..1400013 | - | 771 | WP_004090769.1 | hypothetical protein | - |
| LZ752_RS06385 (LZ752_06385) | 1400124..1400351 | + | 228 | WP_004091377.1 | DUF6290 family protein | - |
| LZ752_RS06390 (LZ752_06390) | 1400335..1400601 | + | 267 | WP_011097988.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LZ752_RS06395 (LZ752_06395) | 1400612..1402060 | - | 1449 | WP_234552890.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1393447..1436358 | 42911 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 10790.57 Da Isoelectric Point: 10.0509
>T230998 WP_004089252.1 NZ_CP090518:1396496-1396792 [Xylella fastidiosa subsp. fastidiosa]
MVELIKTSTFDAWINSLRDRKAAARIQARLDRLALGNPGDVKPVGAGISEMRIDHGPGYRIYFMKHGAVLILLLCGGDKS
SQVRDIEQAKALAALWKD
MVELIKTSTFDAWINSLRDRKAAARIQARLDRLALGNPGDVKPVGAGISEMRIDHGPGYRIYFMKHGAVLILLLCGGDKS
SQVRDIEQAKALAALWKD
Download Length: 297 bp
>T230998 NZ_CP125805:c260517-260095 [Mannheimia bovis]
ATGTTTTTACTCGATACTAATGTGGTCAGCGAACTGCGAAAAGTGAAAAAAGGGATGGCTAATCCAAATGTAGTAGCGTG
GTTGGCAAAGCAAAATCCGAATGATTTTTACATTAATTCTATTGTGCTAATGGAACTGGAACGGGGCGTTTTGGCGATGG
AGCGAAAAGATCCTACGCAAGGTGTTCATCTACGCCATTGGCAAAATCTGTTTCTCAACCAAATTTTGCATAAGCCGATT
TTACCCATTGACGAAACTACCGCCCAAATCTGTGCCAAACTGCATATTCCCGATCACGCCCCTGAAAATGATGCGTGGAT
TGCAGCCTCCGCTATTCAACACCATTTGATTTTGGTTACTCGCAATACAGCTGATTTCGCCAAAACAGGGGCAAAATTGT
TTAACCCCTTTGAGCCACAATAA
ATGTTTTTACTCGATACTAATGTGGTCAGCGAACTGCGAAAAGTGAAAAAAGGGATGGCTAATCCAAATGTAGTAGCGTG
GTTGGCAAAGCAAAATCCGAATGATTTTTACATTAATTCTATTGTGCTAATGGAACTGGAACGGGGCGTTTTGGCGATGG
AGCGAAAAGATCCTACGCAAGGTGTTCATCTACGCCATTGGCAAAATCTGTTTCTCAACCAAATTTTGCATAAGCCGATT
TTACCCATTGACGAAACTACCGCCCAAATCTGTGCCAAACTGCATATTCCCGATCACGCCCCTGAAAATGATGCGTGGAT
TGCAGCCTCCGCTATTCAACACCATTTGATTTTGGTTACTCGCAATACAGCTGATTTCGCCAAAACAGGGGCAAAATTGT
TTAACCCCTTTGAGCCACAATAA
Antitoxin
Download Length: 102 a.a. Molecular weight: 10983.37 Da Isoelectric Point: 5.0941
>AT230998 WP_004089254.1 NZ_CP090518:1396796-1397101 [Xylella fastidiosa subsp. fastidiosa]
MNNETFSRYDTADYLKTEEDIAAYMEAVMEEGGRDNPAFIARALGAVARARNLSQLARDVGMSRQGLDKALSNDGNPSFS
TILKVAKALGLRMSFTPSSMS
MNNETFSRYDTADYLKTEEDIAAYMEAVMEEGGRDNPAFIARALGAVARARNLSQLARDVGMSRQGLDKALSNDGNPSFS
TILKVAKALGLRMSFTPSSMS
Download Length: 306 bp
>AT230998 NZ_CP125805:c260783-260517 [Mannheimia bovis]
ATGAGTGTAATGACCTGCCGTGAATTTAATCAAAAAACCAGCCTTGCCCAAAAATATGCGGAGACCGCACCGGTGATTAT
TACCCATCGAGGTAAGCCGACTTTTGTGTTGTTGAAGTATGAGGATTATCAACCGCAAAAAAACGCTCGAAGCGCCTTAG
ACGCTTTGTTAGATCTGGATCATTCCCCCGATGTGGCGGATATTGAGTTGGAGTTAAAGCCCCGTAGTCGAGCCCAACGT
CCGCCGGTCGATTTTGGAGATGAATGA
ATGAGTGTAATGACCTGCCGTGAATTTAATCAAAAAACCAGCCTTGCCCAAAAATATGCGGAGACCGCACCGGTGATTAT
TACCCATCGAGGTAAGCCGACTTTTGTGTTGTTGAAGTATGAGGATTATCAACCGCAAAAAAACGCTCGAAGCGCCTTAG
ACGCTTTGTTAGATCTGGATCATTCCCCCGATGTGGCGGATATTGAGTTGGAGTTAAAGCCCCGTAGTCGAGCCCAACGT
CCGCCGGTCGATTTTGGAGATGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|