Detailed information of TA system TA230996

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): FicTA/Fic(toxin)
• Location: 1224427..1225223
• Replicon: chromosome
• Accession: NZ_CP090518
• Organism: Xylella fastidiosa subsp. fastidiosa strain Stag's Leap

Toxin (Protein)

• Gene name: VbhT
• Uniprot ID: Q87CQ8
• Locus tag: LZ752_RS05400
• Protein ID: WP_004088112.1
• Coordinates: 1224427..1225038 (-)
• Length: 204 a.a.

Antitoxin (Protein)

• Gene name: VbhA
• Uniprot ID: B2I551
• Locus tag: LZ752_RS05405
• Protein ID: WP_004088114.1
• Coordinates: 1225035..1225223 (-)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ752_RS05355 (LZ752_05355)	1219882..1220769	-	888	WP_012382597.1	YdaU family protein	-
LZ752_RS05360 (LZ752_05360)	1220766..1221554	-	789	WP_011097897.1	Bro-N domain-containing protein	-
LZ752_RS05365 (LZ752_05365)	1221551..1222183	-	633	WP_004088094.1	Bro-N domain-containing protein	-
LZ752_RS05370 (LZ752_05370)	1222180..1222443	-	264	WP_228446177.1	hypothetical protein	-
LZ752_RS05375 (LZ752_05375)	1222461..1222676	-	216	WP_012382598.1	hypothetical protein	-
LZ752_RS05380 (LZ752_05380)	1222706..1222894	-	189	WP_004088102.1	hypothetical protein	-
LZ752_RS05385 (LZ752_05385)	1222922..1223113	-	192	WP_004088104.1	hypothetical protein	-
LZ752_RS05390 (LZ752_05390)	1223372..1223617	-	246	WP_004088108.1	hypothetical protein	-
LZ752_RS05395 (LZ752_05395)	1223702..1224376	+	675	WP_012382600.1	helix-turn-helix transcriptional regulator	-
LZ752_RS05400 (LZ752_05400)	1224427..1225038	-	612	WP_004088112.1	Fic/DOC family protein	Toxin
LZ752_RS05405 (LZ752_05405)	1225035..1225223	-	189	WP_004088114.1	antitoxin VbhA family protein	Antitoxin
LZ752_RS05410 (LZ752_05410)	1225615..1226151	+	537	WP_012382601.1	hypothetical protein	-
LZ752_RS05415 (LZ752_05415)	1226148..1226561	+	414	WP_004088056.1	DUF1566 domain-containing protein	-
LZ752_RS05420 (LZ752_05420)	1226558..1226959	+	402	WP_004088054.1	hypothetical protein	-
LZ752_RS05425 (LZ752_05425)	1226956..1227105	+	150	WP_012382602.1	hypothetical protein	-
LZ752_RS05430 (LZ752_05430)	1227323..1227469	+	147	WP_225621633.1	hypothetical protein	-
LZ752_RS05435 (LZ752_05435)	1227492..1227683	+	192	WP_012382603.1	hypothetical protein	-
LZ752_RS05440 (LZ752_05440)	1227704..1228048	+	345	WP_004088346.1	hypothetical protein	-
LZ752_RS05445 (LZ752_05445)	1228088..1228909	+	822	WP_004088345.1	DUF2303 family protein	-
LZ752_RS05450 (LZ752_05450)	1228925..1229851	+	927	WP_004088344.1	phage recombination protein Bet	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1211524..1234973	23449

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (55-152)

Antitoxin

• Antitoxin VbhA (10-56)

Sequences

Toxin

Protein

• Length: 204 a.a.
• Molecular weight: 22832.60 Da
• Isoelectric Point: 5.1271

>T230996 WP_004088112.1 NZ_CP090518:c1225038-1224427 [Xylella fastidiosa subsp. fastidiosa]
MKYAGDRGDPYLDSETGVLRNLLGIRDQGGLDKIESTLSFLRTSELRERPVKGKFDLAHLQEIHNRLFQDVYDWAGQIRQ
VEISKGNTMFAQQIAIQSAAQQIFGQLAKERFLCGLDAEEFSKRAGDYLGEINVLHPFREGNGRTQREFIAQLAQRAGYR
IDWGVVSQADMIKASIDAYNGDSSGLASIIREGISDQLFKDNE

Nucleotide

• Length: 612 bp

>T230996 NZ_CP125781:c4506197-4505622 [Trabulsiella odontotermitis]
ATGGGGCATTCACCTTTTGCGGTGATCCTCGATGCATGTGTGCTTTATCCGGCAAGGTTGCGGGATTTGTTAATGCATTT
AGGGATAGCGGGTTTATATCAACCAAAGTGGACAGAAGATATTCAGGGCGAATGGTGCAGGAATTTATTGCGTAATCGCC
CGGATATTCCCGGCGAAGCTTTACAACGAACTATTCAGCTAATGAATATGGCATTACCAGATGCTAACGTAACGGGATAT
GAACCTCTCATTGAGAGCCTGGCATTACCTGATAATAATGACAGGCATGTACTTGCCGCCGCAATACGTACCCGGGCAGA
GATTATTGTCACTCTAAATCAAAAAGATTTTCCTCCAGAAGCACTTAGCTCTTTTAATATTGAAGCGCTACATCCCGATG
ATTTTATTTCCGATCTCTTCGACCTGAACCATGCACTGGTACTGGAAGCCGTCAGAAGACAGCGATGCGCCTTAAGACAT
CCACCCATAACGGTGGATGCGTTTCTGGATATGCTTTCTGCGCTGGGTTTACAGCAGACCACTCGGCTACTTAACGATTA
CCGCTACGTCATTTAG

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6837.77 Da
• Isoelectric Point: 4.9859

>AT230996 WP_004088114.1 NZ_CP090518:c1225223-1225035 [Xylella fastidiosa subsp. fastidiosa]
MLTDHEKAERRAVVQSALASQRIEGLEPDAQAVVDAECWARGEMTIAAAVDQYKARVRLQIA

Nucleotide

• Length: 189 bp

>AT230996 NZ_CP125781:c4506655-4506197 [Trabulsiella odontotermitis]
ATGACCACGACAGTTTCTCACCTTAACCTCCCGGACAGCCGGGAGCGCGAGCTGGCGCAGCGAGGGCAGCATCAGCTTAC
CGCTTATCTCTCAACGAAGCTGGAAACGCAGCGCATTTCCATCGTTGGAGATGATGACAAAACACATATTATTGAACTTC
CTGGCAGTGCGATGACCCTGTTGGTGGATATTCTGGGCGAACTGGCGGCGGGAAATGCTGTGCAGATTGTGCCTGTACAG
GCCGAACTCACCACCCAGGAAGCGGCAAATATCCTCAACGTGTCCCGACCGCATATGGTCAAACTGCTGGAACAGGGCCA
CTTACCGTTTCATAAGATCGGCCGTCATCGCAGAATTTTGTTTGCGGACTTGATGAAGTACAAACAGAAGCGCGAACATG
AAAGCCTTGATGCAATGCAGGCGCTGGCCGATCAGGCGCAGGACTTAGGGATGTTGTAA

Structures

Toxin

• AlphaFold DB: Q87CQ8

Antitoxin

• AlphaFold DB: B2I551