Detailed information of TA system TA230992

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 2507288..2507899
• Replicon: chromosome
• Accession: NZ_CP090514
• Organism: Xylella fastidiosa subsp. fastidiosa strain Riv13

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q879T9
• Locus tag: LZ753_RS11245
• Protein ID: WP_011098375.1
• Coordinates: 2507600..2507899 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q879U0
• Locus tag: LZ753_RS11240
• Protein ID: WP_004085003.1
• Coordinates: 2507288..2507596 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ753_RS11205 (LZ753_11205)	2503858..2504619	-	762	WP_004090267.1	Bax inhibitor-1/YccA family protein	-
LZ753_RS11230 (LZ753_11230)	2505958..2506368	-	411	WP_228446157.1	hypothetical protein	-
LZ753_RS11235 (LZ753_11235)	2506357..2507214	+	858	WP_228446158.1	hypothetical protein	-
LZ753_RS11240 (LZ753_11240)	2507288..2507596	-	309	WP_004085003.1	putative addiction module antidote protein	Antitoxin
LZ753_RS11245 (LZ753_11245)	2507600..2507899	-	300	WP_011098375.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LZ753_RS11250 (LZ753_11250)	2507987..2508532	+	546	WP_011098376.1	hypothetical protein	-
LZ753_RS11255 (LZ753_11255)	2508544..2508687	+	144	WP_155115087.1	hypothetical protein	-
LZ753_RS11260 (LZ753_11260)	2508840..2509220	-	381	WP_004089371.1	DUF596 domain-containing protein	-
LZ753_RS11265 (LZ753_11265)	2509225..2510355	-	1131	WP_012382788.1	DUF769 domain-containing protein	-
LZ753_RS11270 (LZ753_11270)	2510663..2511043	-	381	WP_004087391.1	DUF596 domain-containing protein	-
LZ753_RS11275 (LZ753_11275)	2511055..2512416	-	1362	WP_012382789.1	DUF637 domain-containing protein	-
LZ753_RS11280 (LZ753_11280)	2512496..2512639	+	144	WP_155115088.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2460740..2523058	62318

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-98)

Antitoxin

• Uncharacterized protein HI1420 (15-100)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11378.17 Da
• Isoelectric Point: 10.3861

>T230992 WP_011098375.1 NZ_CP090514:c2507899-2507600 [Xylella fastidiosa subsp. fastidiosa]
MTYTLKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Nucleotide

• Length: 300 bp

>T230992 NZ_CP125781:3426759-3426977 [Trabulsiella odontotermitis]
ATGTCAGATAAGCCATTAACCAAAAATGATTATTTGTTGCGTCTGCGACGTTGCCAGTCTATTGATACCCTTGAGCGTGT
GATCGAAAAAAATAAATATGAACTTCCCGACAATGAACTGGCTGTATTTTACTCAGCGGCCGATCATCGTCTCGCTGAAT
TGACGATGAATAAACTTTACGACAAGATCCCGACCTCCGTATGGAAGTTTATCCGGTAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11060.61 Da
• Isoelectric Point: 4.6535

>AT230992 WP_004085003.1 NZ_CP090514:c2507596-2507288 [Xylella fastidiosa subsp. fastidiosa]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Nucleotide

• Length: 309 bp

>AT230992 NZ_CP125781:3426358-3426732 [Trabulsiella odontotermitis]
ATGGACGAATATTCGCCAAAAAGACATGATATCGCACAGCTTAAATTTCTCTGTGAGACCCTGTATCATGATTGCCTTGC
TAACCTCGAGGAGAGCAACCACGGATGGGTTAACGACCCGACCTCTGCGGTTAATCTTCAGTTGAATGAGCTGATTGAGC
ACATTGCGACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGACAATAAACTGATTGCTCAGATTGATGAATACCTA
GACGACACTTTTATGTTGTTCGGTAACTATGGGATTAATGCAGAAGATCTGCAGAAATGGCGGAAGTCCGGGAACAGACT
TTTTCGTTGTTTCACCAATGCGAGCCGGGCTAACCCCGTCAGTCTCTCATGTTAA

Structures

Toxin

• AlphaFold DB: Q879T9

Antitoxin

• AlphaFold DB: A0A060HCD4