Detailed information of TA system TA230991

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1577910..1578496
• Replicon: chromosome
• Accession: NZ_CP090514
• Organism: Xylella fastidiosa subsp. fastidiosa strain Riv13

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q87BV5
• Locus tag: LZ753_RS07190
• Protein ID: WP_004089517.1
• Coordinates: 1578242..1578496 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B2I6C9
• Locus tag: LZ753_RS07185
• Protein ID: WP_004085025.1
• Coordinates: 1577910..1578245 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ753_RS07155 (LZ753_07155)	1573509..1574420	-	912	WP_004089529.1	iron-sulfur cluster carrier protein ApbC	-
LZ753_RS07160 (LZ753_07160)	1574855..1575628	+	774	WP_004089528.1	3-deoxy-manno-octulosonate cytidylyltransferase	-
LZ753_RS07165 (LZ753_07165)	1575625..1576089	+	465	WP_011098056.1	low molecular weight protein-tyrosine-phosphatase	-
LZ753_RS07170 (LZ753_07170)	1576076..1576789	-	714	WP_011098057.1	site-specific DNA-methyltransferase	-
LZ753_RS07175 (LZ753_07175)	1577140..1577421	+	282	WP_011098058.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LZ753_RS07180 (LZ753_07180)	1577431..1577730	+	300	WP_004089519.1	HigA family addiction module antitoxin	-
LZ753_RS07185 (LZ753_07185)	1577910..1578245	-	336	WP_004085025.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LZ753_RS07190 (LZ753_07190)	1578242..1578496	-	255	WP_004089517.1	type II toxin-antitoxin system HicA family toxin	Toxin
LZ753_RS07195 (LZ753_07195)	1578549..1579247	-	699	WP_011098059.1	hypothetical protein	-
LZ753_RS07200 (LZ753_07200)	1579376..1579837	-	462	WP_011098060.1	hypothetical protein	-
LZ753_RS07205 (LZ753_07205)	1579834..1580523	-	690	WP_011098061.1	hypothetical protein	-
LZ753_RS07210 (LZ753_07210)	1580504..1581628	-	1125	WP_234502182.1	YdaU family protein	-
LZ753_RS07215 (LZ753_07215)	1581625..1581879	-	255	WP_012382666.1	hypothetical protein	-
LZ753_RS07220 (LZ753_07220)	1582026..1582400	+	375	WP_004091110.1	conjugal transfer protein	-
LZ753_RS07225 (LZ753_07225)	1582406..1583011	+	606	WP_004091108.1	conjugal transfer protein TrbN	-
LZ753_RS07230 (LZ753_07230)	1583253..1583459	+	207	WP_225621720.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-80)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9639.14 Da
• Isoelectric Point: 11.2766

>T230991 WP_004089517.1 NZ_CP090514:c1578496-1578242 [Xylella fastidiosa subsp. fastidiosa]
MKRKHAKTLSAIYTRPVSANIQWRDIEALFVELGAKVEEREGSRMLVRLFGERRIFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Nucleotide

• Length: 255 bp

>T230991 NZ_CP125781:c2672409-2672306 [Trabulsiella odontotermitis]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12324.07 Da
• Isoelectric Point: 5.6556

>AT230991 WP_004085025.1 NZ_CP090514:c1578245-1577910 [Xylella fastidiosa subsp. fastidiosa]
MKNIMTIESFKAIITYDPEIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACKEDSVEPRKCYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEVHT

Nucleotide

• Length: 336 bp

>AT230991 NZ_CP125781:2672300-2672462 [Trabulsiella odontotermitis]
ACAAATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTCGCCTTGCCCTTTAAGAATAGATGACCGTGCCAGGTTTTCCAGTCTGCGACTAAAGTGG
TCA

Structures

Toxin

• AlphaFold DB: Q87BV5

Antitoxin

• AlphaFold DB: A0A060HAK5