Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pasABC/RelE-HTH |
| Location | 1388839..1389316 | Replicon | chromosome |
| Accession | NZ_CP090514 | ||
| Organism | Xylella fastidiosa subsp. fastidiosa strain Riv13 | ||
Toxin (Protein)
| Gene name | pasB | Uniprot ID | Q87CA4 |
| Locus tag | LZ753_RS06295 | Protein ID | WP_011097988.1 |
| Coordinates | 1389050..1389316 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | pasA | Uniprot ID | A0A7G7TPD2 |
| Locus tag | LZ753_RS06290 | Protein ID | WP_004091377.1 |
| Coordinates | 1388839..1389066 (+) | Length | 76 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZ753_RS06250 (LZ753_06250) | 1383966..1385111 | - | 1146 | WP_011097984.1 | baseplate J/gp47 family protein | - |
| LZ753_RS06255 (LZ753_06255) | 1385210..1385506 | + | 297 | WP_004089252.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LZ753_RS06260 (LZ753_06260) | 1385510..1385815 | + | 306 | WP_004089254.1 | putative addiction module antidote protein | - |
| LZ753_RS06265 (LZ753_06265) | 1385826..1386179 | - | 354 | WP_234502177.1 | hypothetical protein | - |
| LZ753_RS06270 (LZ753_06270) | 1386176..1386817 | - | 642 | WP_012382583.1 | Gp138 family membrane-puncturing spike protein | - |
| LZ753_RS06275 (LZ753_06275) | 1386814..1387644 | - | 831 | WP_012382584.1 | hypothetical protein | - |
| LZ753_RS06280 (LZ753_06280) | 1387641..1387958 | - | 318 | WP_011097873.1 | hypothetical protein | - |
| LZ753_RS06285 (LZ753_06285) | 1387958..1388728 | - | 771 | WP_004090769.1 | hypothetical protein | - |
| LZ753_RS06290 (LZ753_06290) | 1388839..1389066 | + | 228 | WP_004091377.1 | DUF6290 family protein | Antitoxin |
| LZ753_RS06295 (LZ753_06295) | 1389050..1389316 | + | 267 | WP_011097988.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LZ753_RS06300 (LZ753_06300) | 1389327..1391120 | - | 1794 | WP_228446142.1 | phage tail tape measure protein | - |
| LZ753_RS06305 (LZ753_06305) | 1391173..1391337 | - | 165 | WP_014607750.1 | hypothetical protein | - |
| LZ753_RS06310 (LZ753_06310) | 1391364..1391786 | - | 423 | WP_004085005.1 | putative phage tail assembly chaperone | - |
| LZ753_RS06315 (LZ753_06315) | 1391783..1392220 | - | 438 | WP_011097990.1 | DUF3277 family protein | - |
| LZ753_RS06320 (LZ753_06320) | 1392230..1392463 | - | 234 | WP_011097991.1 | DUF3383 family protein | - |
| LZ753_RS06325 (LZ753_06325) | 1392480..1393358 | - | 879 | WP_012382645.1 | RNA-guided endonuclease TnpB family protein | - |
| LZ753_RS06330 (LZ753_06330) | 1393524..1393685 | - | 162 | WP_014607806.1 | helix-turn-helix domain-containing protein | - |
| LZ753_RS06335 (LZ753_06335) | 1393679..1394284 | - | 606 | Protein_1237 | IS607 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1382161..1425075 | 42914 | |
| - | flank | IS/Tn | - | - | 1393679..1393900 | 221 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10163.79 Da Isoelectric Point: 10.6086
>T230990 WP_011097988.1 NZ_CP090514:1389050-1389316 [Xylella fastidiosa subsp. fastidiosa]
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSSGKALTGPLGGFWRYRVGDFRVVCAIQDSVLRVLVVRV
GHRGEIYR
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSSGKALTGPLGGFWRYRVGDFRVVCAIQDSVLRVLVVRV
GHRGEIYR
Download Length: 267 bp
>T230990 NZ_CP125781:c1237475-1237152 [Trabulsiella odontotermitis]
ATGCAAATTTCATCTGTACCGGCCACGGTGCCGGTTTCGTCACGCCTGTCGCCCGTAATGGTGTGGCAGCAGCTGTTAAC
GTATCTACTGGAGCACCACTACGGCCTGACACTCAACGACACACCATTTCATGACGACACGGCCATTCAGGGACATATCG
AGGCGGGGATAACTCTAGCCGATGCGGTTAATTTCCTGGTCGAAAAGTACGAACTCGTTCGTATCGACCGGAAGGGATTT
TCATGGCAAGAGCAAACGCCCTTCATTACCGCAACGGATATTCTGCGTGCCAAAAAGAGCATCGGGCTGTTGCCCAGATC
TTAA
ATGCAAATTTCATCTGTACCGGCCACGGTGCCGGTTTCGTCACGCCTGTCGCCCGTAATGGTGTGGCAGCAGCTGTTAAC
GTATCTACTGGAGCACCACTACGGCCTGACACTCAACGACACACCATTTCATGACGACACGGCCATTCAGGGACATATCG
AGGCGGGGATAACTCTAGCCGATGCGGTTAATTTCCTGGTCGAAAAGTACGAACTCGTTCGTATCGACCGGAAGGGATTT
TCATGGCAAGAGCAAACGCCCTTCATTACCGCAACGGATATTCTGCGTGCCAAAAAGAGCATCGGGCTGTTGCCCAGATC
TTAA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8615.63 Da Isoelectric Point: 5.0958
>AT230990 WP_004091377.1 NZ_CP090514:1388839-1389066 [Xylella fastidiosa subsp. fastidiosa]
MATSIRLSPEMEQRLNSLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLGLDD
MATSIRLSPEMEQRLNSLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLGLDD
Download Length: 228 bp
>AT230990 NZ_CP125781:c1237830-1237507 [Trabulsiella odontotermitis]
ATGCAAAATTCATGGGGACTGAAGCGCGACATCTCGCCGTGCTTCGGTGCAAGGCTTGTGCAGGAAGGCTGTCGCCTGCA
TTTTCTGGCGGACCGTGCAGGTATTAGTGGTACGTTTAACGAGGAGGAGGCACTGTGTCTGGATCAGGCATTTCCGCTAG
TGATGAAACAGCTTGAATTGATGCTGACAACCGGTGAACTGAATCCGCGCCATCAGCATTGCGTCACGTTGTATCATAAC
GGACTAACTTGTGAAGCTGACACTCTCGGCTCTCATGGCTATGTTTACATCGTTATTTATCCTCAGGCATTTGCAACCAG
GTAA
ATGCAAAATTCATGGGGACTGAAGCGCGACATCTCGCCGTGCTTCGGTGCAAGGCTTGTGCAGGAAGGCTGTCGCCTGCA
TTTTCTGGCGGACCGTGCAGGTATTAGTGGTACGTTTAACGAGGAGGAGGCACTGTGTCTGGATCAGGCATTTCCGCTAG
TGATGAAACAGCTTGAATTGATGCTGACAACCGGTGAACTGAATCCGCGCCATCAGCATTGCGTCACGTTGTATCATAAC
GGACTAACTTGTGAAGCTGACACTCTCGGCTCTCATGGCTATGTTTACATCGTTATTTATCCTCAGGCATTTGCAACCAG
GTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A060HDH1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7G7TPD2 |