Detailed information of TA system TA230988

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 1303926..1304457
• Replicon: chromosome
• Accession: NZ_CP090514
• Organism: Xylella fastidiosa subsp. fastidiosa strain Riv13

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q87CH1
• Locus tag: LZ753_RS05815
• Protein ID: WP_004090909.1
• Coordinates: 1304176..1304457 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: Q87CH2
• Locus tag: LZ753_RS05810
• Protein ID: WP_004090907.1
• Coordinates: 1303926..1304189 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ753_RS05785 (LZ753_05785)	1299152..1300330	-	1179	WP_011097931.1	phage tail sheath family protein	-
LZ753_RS05790 (LZ753_05790)	1300395..1301987	-	1593	WP_011097932.1	tail fiber domain-containing protein	-
LZ753_RS05795 (LZ753_05795)	1301995..1302552	-	558	WP_011097610.1	phage tail protein I	-
LZ753_RS05800 (LZ753_05800)	1302545..1303438	-	894	WP_011097611.1	baseplate J/gp47 family protein	-
LZ753_RS05805 (LZ753_05805)	1303438..1303800	-	363	WP_014607615.1	GPW/gp25 family protein	-
LZ753_RS05810 (LZ753_05810)	1303926..1304189	+	264	WP_004090907.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LZ753_RS05815 (LZ753_05815)	1304176..1304457	+	282	WP_004090909.1	type II toxin-antitoxin system YafQ family toxin	Toxin
LZ753_RS05820 (LZ753_05820)	1304494..1305081	-	588	WP_011097612.1	phage baseplate assembly protein V	-
LZ753_RS05825 (LZ753_05825)	1305078..1305620	-	543	WP_011097613.1	hypothetical protein	-
LZ753_RS05830 (LZ753_05830)	1305596..1306117	-	522	WP_011097614.1	hypothetical protein	-
LZ753_RS05835 (LZ753_05835)	1306114..1306437	-	324	WP_011097935.1	hypothetical protein	-
LZ753_RS05840 (LZ753_05840)	1306437..1306697	-	261	WP_011097616.1	hypothetical protein	-
LZ753_RS05845 (LZ753_05845)	1306715..1308589	-	1875	WP_011097936.1	phage major capsid protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1290513..1337235	46722

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-70)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10936.37 Da
• Isoelectric Point: 7.2205

>T230988 WP_004090909.1 NZ_CP090514:1304176-1304457 [Xylella fastidiosa subsp. fastidiosa]
MRRISQTGQFKRDYKREAKGQHRATLDEELIHVLEALTCDHPLEPRHHDHALTGDWKDHRDCHIKPDLVLIYRKPDNETL
QLVRIGSHSELGL

Nucleotide

• Length: 282 bp

>T230988 NZ_CP125781:539742-540062 [Trabulsiella odontotermitis]
ATGCACATTTCAACTGTACCGGCCACGGTGCCGGTTTCGTCACGCTTGTCGCCCATACAGGTCTGGCAGCAACTGCTAAC
ATATCTGCTGGACCACCATTACGGCCTGACACTTGACGATACGCCTTTCCACGACGATGCGGCCATTCTGGAACATATCG
AGGCGGGAATCACGCTCGCCGATGCGGTTAATTTCCTAGTGGAACGTTATGAACTGGTACGCATTGATCGCAAAGGATTC
ACCTGGCAGGAGCAGACACCGTTCCTGACCGCCACCGATATTCTCAGAGCAAGGCGAGCTACCGGATTAATAAATACCTG
A

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9495.95 Da
• Isoelectric Point: 5.6033

>AT230988 WP_004090907.1 NZ_CP090514:1303926-1304189 [Xylella fastidiosa subsp. fastidiosa]
MSANAVVRARVDAHIKEEASTVLATMGLSVSDAFRMMLTRIAREKALPFEPLVPNETTIAAMREARAGHLKSFDSIEALM
ADLHAED

Nucleotide

• Length: 264 bp

>AT230988 NZ_CP125781:539382-539705 [Trabulsiella odontotermitis]
ATGCCATTCATACCACCCCATGAATGGAGGCTACAAAGCGATATCACCCCACGATTTGGCGCTAGATTAGTGCAGGAAGG
TAACCGTCTGTATTACCTGGCTGACAGGGCTGGATTGACGGGGGAATTTACCTTGAAGCAACTGCAGAAACTGGATCAGG
CTTTCCCGCTGTTTATCCGTCAATTGGAAGCAATGCTGCGTTCCGGTGAGCTAAATCCACAGCAGCAACGTCAGGTGACC
ATTCAACTTGCGAGTTTAACCTGCATAGCTGATACCCGTGGTAGCTGCGGTTACGTTTACATTTCTATTTATCCAACCCC
GTAA

Structures

Toxin

• AlphaFold DB: Q87CH1

Antitoxin

• AlphaFold DB: Q87CH2