Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | FicTA/Fic(toxin) |
| Location | 1213054..1213850 | Replicon | chromosome |
| Accession | NZ_CP090514 | ||
| Organism | Xylella fastidiosa subsp. fastidiosa strain Riv13 | ||
Toxin (Protein)
| Gene name | VbhT | Uniprot ID | Q87CQ8 |
| Locus tag | LZ753_RS05310 | Protein ID | WP_004088112.1 |
| Coordinates | 1213054..1213665 (-) | Length | 204 a.a. |
Antitoxin (Protein)
| Gene name | VbhA | Uniprot ID | B2I551 |
| Locus tag | LZ753_RS05315 | Protein ID | WP_004088114.1 |
| Coordinates | 1213662..1213850 (-) | Length | 63 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZ753_RS05265 (LZ753_05265) | 1208509..1209396 | - | 888 | WP_012382597.1 | YdaU family protein | - |
| LZ753_RS05270 (LZ753_05270) | 1209393..1210181 | - | 789 | WP_011097897.1 | Bro-N domain-containing protein | - |
| LZ753_RS05275 (LZ753_05275) | 1210178..1210810 | - | 633 | WP_004088094.1 | Bro-N domain-containing protein | - |
| LZ753_RS05280 (LZ753_05280) | 1210807..1211070 | - | 264 | WP_228446177.1 | hypothetical protein | - |
| LZ753_RS05285 (LZ753_05285) | 1211088..1211303 | - | 216 | WP_012382598.1 | hypothetical protein | - |
| LZ753_RS05290 (LZ753_05290) | 1211333..1211521 | - | 189 | WP_004088102.1 | hypothetical protein | - |
| LZ753_RS05295 (LZ753_05295) | 1211549..1211740 | - | 192 | WP_004088104.1 | hypothetical protein | - |
| LZ753_RS05300 (LZ753_05300) | 1211999..1212244 | - | 246 | WP_004088108.1 | hypothetical protein | - |
| LZ753_RS05305 (LZ753_05305) | 1212329..1213003 | + | 675 | WP_012382600.1 | helix-turn-helix transcriptional regulator | - |
| LZ753_RS05310 (LZ753_05310) | 1213054..1213665 | - | 612 | WP_004088112.1 | Fic/DOC family protein | Toxin |
| LZ753_RS05315 (LZ753_05315) | 1213662..1213850 | - | 189 | WP_004088114.1 | antitoxin VbhA family protein | Antitoxin |
| LZ753_RS05320 (LZ753_05320) | 1214242..1214778 | + | 537 | WP_012382601.1 | hypothetical protein | - |
| LZ753_RS05325 (LZ753_05325) | 1214775..1215188 | + | 414 | WP_004088056.1 | DUF1566 domain-containing protein | - |
| LZ753_RS05330 (LZ753_05330) | 1215185..1215586 | + | 402 | WP_004088054.1 | hypothetical protein | - |
| LZ753_RS05335 (LZ753_05335) | 1215583..1215732 | + | 150 | WP_012382602.1 | hypothetical protein | - |
| LZ753_RS05340 (LZ753_05340) | 1215950..1216096 | + | 147 | WP_225621633.1 | hypothetical protein | - |
| LZ753_RS05345 (LZ753_05345) | 1216119..1216310 | + | 192 | WP_012382603.1 | hypothetical protein | - |
| LZ753_RS05350 (LZ753_05350) | 1216331..1216675 | + | 345 | WP_004088346.1 | hypothetical protein | - |
| LZ753_RS05355 (LZ753_05355) | 1216715..1217536 | + | 822 | WP_004088345.1 | DUF2303 family protein | - |
| LZ753_RS05360 (LZ753_05360) | 1217552..1218478 | + | 927 | WP_004088344.1 | phage recombination protein Bet | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 204 a.a. Molecular weight: 22832.60 Da Isoelectric Point: 5.1271
>T230987 WP_004088112.1 NZ_CP090514:c1213665-1213054 [Xylella fastidiosa subsp. fastidiosa]
MKYAGDRGDPYLDSETGVLRNLLGIRDQGGLDKIESTLSFLRTSELRERPVKGKFDLAHLQEIHNRLFQDVYDWAGQIRQ
VEISKGNTMFAQQIAIQSAAQQIFGQLAKERFLCGLDAEEFSKRAGDYLGEINVLHPFREGNGRTQREFIAQLAQRAGYR
IDWGVVSQADMIKASIDAYNGDSSGLASIIREGISDQLFKDNE
MKYAGDRGDPYLDSETGVLRNLLGIRDQGGLDKIESTLSFLRTSELRERPVKGKFDLAHLQEIHNRLFQDVYDWAGQIRQ
VEISKGNTMFAQQIAIQSAAQQIFGQLAKERFLCGLDAEEFSKRAGDYLGEINVLHPFREGNGRTQREFIAQLAQRAGYR
IDWGVVSQADMIKASIDAYNGDSSGLASIIREGISDQLFKDNE
Download Length: 612 bp
>T230987 NZ_CP125762:c3913644-3913294 [Bacillus subtilis]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG
Antitoxin
Download Length: 63 a.a. Molecular weight: 6837.77 Da Isoelectric Point: 4.9859
>AT230987 WP_004088114.1 NZ_CP090514:c1213850-1213662 [Xylella fastidiosa subsp. fastidiosa]
MLTDHEKAERRAVVQSALASQRIEGLEPDAQAVVDAECWARGEMTIAAAVDQYKARVRLQIA
MLTDHEKAERRAVVQSALASQRIEGLEPDAQAVVDAECWARGEMTIAAAVDQYKARVRLQIA
Download Length: 189 bp
>AT230987 NZ_CP125762:c3913930-3913649 [Bacillus subtilis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|