Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 627806..628347 Replicon chromosome
Accession NZ_CP090514
Organism Xylella fastidiosa subsp. fastidiosa strain Riv13

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LZ753_RS02700 Protein ID WP_020853079.1
Coordinates 628024..628347 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LZ753_RS02695 Protein ID WP_234502210.1
Coordinates 627806..628027 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ753_RS02645 (LZ753_02645) 622961..623089 - 129 WP_011097859.1 hypothetical protein -
LZ753_RS02650 (LZ753_02650) 623109..623360 - 252 WP_004089393.1 hypothetical protein -
LZ753_RS02655 (LZ753_02655) 623486..623797 - 312 WP_011097860.1 single-stranded DNA-binding protein -
LZ753_RS02660 (LZ753_02660) 623838..625013 - 1176 WP_011097861.1 replication initiation factor domain-containing protein -
LZ753_RS02665 (LZ753_02665) 625630..625767 - 138 WP_161594839.1 hypothetical protein -
LZ753_RS02670 (LZ753_02670) 625787..626050 - 264 WP_012382483.1 hypothetical protein -
LZ753_RS02675 (LZ753_02675) 626043..626327 - 285 WP_004091276.1 hypothetical protein -
LZ753_RS02680 (LZ753_02680) 626350..626646 - 297 WP_004091275.1 hypothetical protein -
LZ753_RS02685 (LZ753_02685) 626633..626905 - 273 WP_004091274.1 hypothetical protein -
LZ753_RS02695 (LZ753_02695) 627806..628027 + 222 WP_234502210.1 antitoxin MazE family protein Antitoxin
LZ753_RS02700 (LZ753_02700) 628024..628347 + 324 WP_020853079.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LZ753_RS02705 (LZ753_02705) 628488..628820 - 333 WP_234502211.1 hypothetical protein -
LZ753_RS02710 (LZ753_02710) 628807..629988 - 1182 WP_234502212.1 replication initiation factor domain-containing protein -
LZ753_RS02720 (LZ753_02720) 630607..630813 - 207 WP_155115096.1 hypothetical protein -
LZ753_RS02725 (LZ753_02725) 631214..631354 + 141 WP_012382487.1 hypothetical protein -
LZ753_RS02730 (LZ753_02730) 631357..631659 + 303 WP_004087389.1 hypothetical protein -
LZ753_RS02735 (LZ753_02735) 632117..632302 + 186 WP_012337703.1 hypothetical protein -
LZ753_RS02740 (LZ753_02740) 632618..632992 + 375 Protein_522 terminase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 617822..633454 15632


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-105)

Antitoxin

Antitoxin MazE-like

(9-72)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11808.87 Da        Isoelectric Point: 7.9848

>T230986 WP_020853079.1 NZ_CP090514:628024-628347 [Xylella fastidiosa subsp. fastidiosa]
MIQRGDLVAVSLQGDYGKPRPALIVQSDLLTELDSVVLCPVTSDLRNAIFRVTVEPTPANGLRTLSQVMVDKISTLPRNK
INEPFGRINDERMKAIERALLLIVGII

Download         Length: 324 bp

>T230986 NZ_CP125762:3083222-3083968 [Bacillus subtilis]
ATGGTTTTATTCTTTCAGATCATGGTCTGGTGCATCGTGGCCGGACTGGGGTTATACGTGTATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATTCGGAAAACTTGGTATTTGCTGTTTGTTCTGGGCGCTATGGTATACTGGA
CATATGAGCCCACTTCCCTATTTACCCACTGGGAACGGTATCTCATTGTCGCAGTCAGTTTTGCTTTGATTGATGCTTTT
ATCTTCTTAAGTGCATATGTCAAAAAACTGGCCGGCAGCGAGCTTGAAACAGACACAAGAGAAATTCTTGAAGAAAACAA
CGAAATGCTCCACATGTATCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAACCGATCCATGTTTATTATG
GAAGTATAGATGCTTATGCTGAAGGTATTGATAAGCTGCTGAAAACCTATGCTGATAAAATGAACTTAACGGCTTCTCTT
TGCCACTATTCGACACAGGCTGATAAAGACCGGTTAACCGAGCATATGGATGATCCGGCAGATGTACAAACACGGCTCGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCTTTTACCATCGAGACACAGAACTATGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTATTTACGTCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8564.77 Da        Isoelectric Point: 9.1478

>AT230986 WP_234502210.1 NZ_CP090514:627806-628027 [Xylella fastidiosa subsp. fastidiosa]
MTSIHRPDSKVVRHRKQMRAAGLRPVQFWVPDTHTPEFAAEIQSQCRALKNEQAEADVLRFTEKAITYIEDWK

Download         Length: 222 bp

>AT230986 NZ_CP125762:3083968-3084138 [Bacillus subtilis]
ATGGAACGTGCGTTTCAAAACAGATGCGAGCCCAGAGCGGCGAAGCCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCATACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References