Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1630759..1631281 Replicon chromosome
Accession NZ_CP090513
Organism Xylella fastidiosa subsp. multiplex strain Red Oak 8

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag LZ751_RS07330 Protein ID WP_004085905.1
Coordinates 1630994..1631281 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A060HDF9
Locus tag LZ751_RS07325 Protein ID WP_004085758.1
Coordinates 1630759..1631001 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ751_RS07295 (LZ751_07295) 1626169..1626351 + 183 WP_027700467.1 hypothetical protein -
LZ751_RS07300 (LZ751_07300) 1626635..1627561 - 927 WP_004085766.1 Grx4 family monothiol glutaredoxin -
LZ751_RS07305 (LZ751_07305) 1627660..1628403 + 744 WP_225621865.1 polysaccharide deacetylase family protein -
LZ751_RS07310 (LZ751_07310) 1629047..1629238 - 192 WP_021358405.1 hypothetical protein -
LZ751_RS07315 (LZ751_07315) 1629656..1630075 - 420 WP_004085763.1 putative toxin-antitoxin system toxin component, PIN family -
LZ751_RS07320 (LZ751_07320) 1630075..1630314 - 240 WP_004085761.1 ribbon-helix-helix domain-containing protein -
LZ751_RS07325 (LZ751_07325) 1630759..1631001 + 243 WP_004085758.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
LZ751_RS07330 (LZ751_07330) 1630994..1631281 + 288 WP_004085905.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ751_RS07335 (LZ751_07335) 1631369..1631935 + 567 WP_004085755.1 recombinase family protein -
LZ751_RS07340 (LZ751_07340) 1631988..1633184 - 1197 WP_012337730.1 RNA-guided endonuclease TnpB family protein -
LZ751_RS07345 (LZ751_07345) 1633178..1633804 - 627 WP_038230952.1 IS607 family transposase -
LZ751_RS07350 (LZ751_07350) 1634034..1635308 - 1275 WP_012337985.1 pyridoxal phosphate-dependent aminotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1629253..1650550 21297
- flank IS/Tn - - 1631369..1631935 566


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-90)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11159.64 Da        Isoelectric Point: 5.9570

>T230981 WP_004085905.1 NZ_CP090513:1630994-1631281 [Xylella fastidiosa subsp. multiplex]
MAKSYRLTPLAEADLEEIWFYTFRHWSIEQADSYHRSLVAVFEGLAAGTKQGCPSVLPDFNKYLCGSHVVYFMDYADHLD
IIRILHQRQDTERYL

Download         Length: 288 bp

>T230981 NZ_CP125762:c2158982-2158866 [Bacillus subtilis]
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8774.77 Da        Isoelectric Point: 6.9881

>AT230981 WP_004085758.1 NZ_CP090513:1630759-1631001 [Xylella fastidiosa subsp. multiplex]
MSRNTSVALGPHFTSFIDAQVQGGRYGTASDVVRAGLRLLEEHETKVKALQDALNVGHQSGEPRPFDSEVFLSRMHTQHG

Download         Length: 243 bp

>AT230981 NZ_CP125762:2158692-2158871 [Bacillus subtilis]
AATGATACAATTATATAATTATTTTTTGCATTTTGTTTAATTAAATGCATAAAATAAAAAGACCAGGGTGTTGGTAGCAC
CCTGGCTCTGTACAAAAGCTGCCCATCAAAGGGCTTGCTCGTTGTCAAATCTGCGTAGGCCTAACCCTTCAGGTGTCCAA
ACTCAAGGGAAGGTCTATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A060HDF9

References