Detailed information of TA system TA230980

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 1359293..1359770
• Replicon: chromosome
• Accession: NZ_CP090513
• Organism: Xylella fastidiosa subsp. multiplex strain Red Oak 8

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: LZ751_RS06025
• Protein ID: WP_004087087.1
• Coordinates: 1359504..1359770 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A7G7TPD2
• Locus tag: LZ751_RS06020
• Protein ID: WP_004091377.1
• Coordinates: 1359293..1359520 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ751_RS05985 (LZ751_05985)	1354485..1355045	-	561	WP_004084996.1	DUF2612 domain-containing protein	-
LZ751_RS05990 (LZ751_05990)	1355042..1356187	-	1146	WP_012337888.1	baseplate J/gp47 family protein	-
LZ751_RS05995 (LZ751_05995)	1356280..1356633	-	354	WP_012337889.1	hypothetical protein	-
LZ751_RS06000 (LZ751_06000)	1356630..1357271	-	642	WP_012337890.1	Gp138 family membrane-puncturing spike protein	-
LZ751_RS06005 (LZ751_06005)	1357268..1358098	-	831	WP_004085000.1	hypothetical protein	-
LZ751_RS06010 (LZ751_06010)	1358095..1358412	-	318	WP_004085001.1	hypothetical protein	-
LZ751_RS06015 (LZ751_06015)	1358412..1359182	-	771	WP_012337891.1	hypothetical protein	-
LZ751_RS06020 (LZ751_06020)	1359293..1359520	+	228	WP_004091377.1	DUF6290 family protein	Antitoxin
LZ751_RS06025 (LZ751_06025)	1359504..1359770	+	267	WP_004087087.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LZ751_RS06030 (LZ751_06030)	1359781..1361421	-	1641	WP_228762187.1	phage tail tape measure protein	-
LZ751_RS06035 (LZ751_06035)	1361627..1361791	-	165	WP_014607750.1	hypothetical protein	-
LZ751_RS06040 (LZ751_06040)	1361818..1362240	-	423	WP_012337893.1	putative phage tail assembly chaperone	-
LZ751_RS06045 (LZ751_06045)	1362237..1362674	-	438	WP_004085006.1	DUF3277 family protein	-
LZ751_RS06050 (LZ751_06050)	1362684..1364180	-	1497	WP_012337894.1	DUF3383 domain-containing protein	-
LZ751_RS06055 (LZ751_06055)	1364181..1364714	-	534	WP_004085008.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1353237..1375859	22622

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10207.80 Da
• Isoelectric Point: 10.3398

>T230980 WP_004087087.1 NZ_CP090513:1359504-1359770 [Xylella fastidiosa subsp. multiplex]
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSSGKALTGPLGGFWRYRVGDFRVVCDIQDSVLRVLVVRV
GHRGEIYR

Nucleotide

• Length: 267 bp

>T230980 NZ_CP090513:1359504-1359770 [Xylella fastidiosa subsp. multiplex]
TTGGCCTGGACGATTGATTACACCGACACGGCCAAGCAGCAGTTACGCAAGCTCGACAAGCACATGGCACGGCGCATTGT
CGATTTCATGGATGAGCGCATCGCCGGACTAGAAAATCCACGCAGCAGTGGTAAAGCATTAACCGGACCACTTGGTGGCT
TTTGGCGTTATCGTGTTGGTGATTTTCGGGTCGTCTGCGACATTCAAGATAGCGTTTTGCGCGTCCTTGTAGTGCGTGTT
GGTCACCGGGGCGAGATTTACCGATAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8615.63 Da
• Isoelectric Point: 5.0958

>AT230980 WP_004091377.1 NZ_CP090513:1359293-1359520 [Xylella fastidiosa subsp. multiplex]
MATSIRLSPEMEQRLNSLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLGLDD

Nucleotide

• Length: 228 bp

>AT230980 NZ_CP090513:1359293-1359520 [Xylella fastidiosa subsp. multiplex]
ATGGCGACTTCGATTCGCCTCTCTCCTGAAATGGAGCAAAGGCTTAACTCTCTTGCCTCCCATACGGGACGCACAAAGGC
TTACTACCTGCGTGAAATCATTGAGCATGGCATTGAGGAAATGGAGGATTACTACCTTGCTGCCGATGTGTTGGAGCGTG
TCCGTCATGGACAAGAACAGGTGCATTCTGCTGCCGACGTGAGGAAAACGCTTGGCCTGGACGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A7G7TPD2