Detailed information of TA system TA230979

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): FicTA/Fic(toxin)
• Location: 1239989..1240785
• Replicon: chromosome
• Accession: NZ_CP090513
• Organism: Xylella fastidiosa subsp. multiplex strain Red Oak 8

Toxin (Protein)

• Gene name: VbhT
• Uniprot ID: -
• Locus tag: LZ751_RS05425
• Protein ID: WP_004087040.1
• Coordinates: 1239989..1240600 (-)
• Length: 204 a.a.

Antitoxin (Protein)

• Gene name: VbhA
• Uniprot ID: A0A060HF63
• Locus tag: LZ751_RS05430
• Protein ID: WP_004087046.1
• Coordinates: 1240597..1240785 (-)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ751_RS05400 (LZ751_05400)	1237284..1237865	-	582	WP_012337852.1	Bro-N domain-containing protein	-
LZ751_RS05405 (LZ751_05405)	1238125..1238508	-	384	WP_012337854.1	hypothetical protein	-
LZ751_RS05410 (LZ751_05410)	1238596..1238925	-	330	WP_021358651.1	hypothetical protein	-
LZ751_RS05415 (LZ751_05415)	1238915..1239160	-	246	WP_012337855.1	hypothetical protein	-
LZ751_RS05420 (LZ751_05420)	1239159..1239938	+	780	WP_021358652.1	helix-turn-helix transcriptional regulator	-
LZ751_RS05425 (LZ751_05425)	1239989..1240600	-	612	WP_004087040.1	Fic/DOC family protein	Toxin
LZ751_RS05430 (LZ751_05430)	1240597..1240785	-	189	WP_004087046.1	antitoxin VbhA family protein	Antitoxin
LZ751_RS05435 (LZ751_05435)	1241166..1241570	+	405	WP_012337857.1	hypothetical protein	-
LZ751_RS05440 (LZ751_05440)	1241567..1242028	+	462	WP_012337858.1	DUF1566 domain-containing protein	-
LZ751_RS05445 (LZ751_05445)	1242025..1242432	+	408	WP_012337859.1	hypothetical protein	-
LZ751_RS05450 (LZ751_05450)	1242429..1242620	+	192	WP_004086069.1	hypothetical protein	-
LZ751_RS05455 (LZ751_05455)	1242682..1243221	-	540	Protein_1068	SNF2-related protein	-
LZ751_RS05460 (LZ751_05460)	1243306..1243710	+	405	WP_004085029.1	hypothetical protein	-
LZ751_RS05465 (LZ751_05465)	1243712..1243990	-	279	WP_012337663.1	VRR-NUC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1212096..1263041	50945

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (55-152)

Antitoxin

• Antitoxin VbhA (10-56)

Sequences

Toxin

Protein

• Length: 204 a.a.
• Molecular weight: 22961.76 Da
• Isoelectric Point: 5.1271

>T230979 WP_004087040.1 NZ_CP090513:c1240600-1239989 [Xylella fastidiosa subsp. multiplex]
MKYAGDRGDPYLDSETGVLRNLLGIRDQGWLDKIESTLSFLRTSELRERPVKGKFDLAHLQEIHNRLFQDVYDWAGQIRQ
VEISKGNTMFAQQIAIQSAAQQIFGQLAKERFLCGLDAEEFSKRAGDYLGEINVLHPFREGNGRTQREFIAQLAQRAGYR
IDWGVVSQADMIKASIDAYNGDSSGLASIIREGISDQLFKDNE

Nucleotide

• Length: 612 bp

>T230979 NZ_CP125762:2078478-2078654 [Bacillus subtilis]
GTGCTTGAGAAAATGGGTATCGTAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGGTAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6855.80 Da
• Isoelectric Point: 4.9859

>AT230979 WP_004087046.1 NZ_CP090513:c1240785-1240597 [Xylella fastidiosa subsp. multiplex]
MLTDHEKAERRAVVQSALASQRIEGLEPDAQAVVDAECWARGEMTIAAAVDQYKARVRLQMA

Nucleotide

• Length: 189 bp

>AT230979 NZ_CP125762:c2078695-2078595 [Bacillus subtilis]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT

Structures

Antitoxin

• AlphaFold DB: A0A060HF63