230972

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 19228..19711 Replicon plasmid pXF26-Oak35874
Accession NZ_CP090512
Organism Xylella fastidiosa subsp. multiplex strain Oak 35874

Toxin (Protein)


Gene name pasB Uniprot ID -
Locus tag LZ754_RS12205 Protein ID WP_234500012.1
Coordinates 19228..19497 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A060HE94
Locus tag LZ754_RS12210 Protein ID WP_038211605.1
Coordinates 19481..19711 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ754_RS12170 (LZ754_12170) 15703..16086 - 384 WP_234500011.1 VirB3 family type IV secretion system protein -
LZ754_RS12175 (LZ754_12175) 16091..16411 - 321 WP_014607308.1 TrbC/VirB2 family protein -
LZ754_RS12180 (LZ754_12180) 16414..16893 - 480 WP_080715118.1 hypothetical protein -
LZ754_RS12185 (LZ754_12185) 16896..17075 - 180 WP_014607310.1 hypothetical protein -
LZ754_RS12190 (LZ754_12190) 17899..18258 + 360 WP_038211603.1 hypothetical protein -
LZ754_RS12195 (LZ754_12195) 18352..19023 - 672 WP_013087963.1 restriction endonuclease -
LZ754_RS12200 (LZ754_12200) 19048..19176 + 129 WP_234056444.1 type II toxin-antitoxin system PemK/MazF family toxin -
LZ754_RS12205 (LZ754_12205) 19228..19497 - 270 WP_234500012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ754_RS12210 (LZ754_12210) 19481..19711 - 231 WP_038211605.1 DUF6290 family protein Antitoxin
LZ754_RS12215 (LZ754_12215) 19888..20490 + 603 WP_013087965.1 recombinase family protein -
LZ754_RS12220 (LZ754_12220) 20487..21353 + 867 WP_128723949.1 plasmid replication initiator TrfA -
LZ754_RS12225 (LZ754_12225) 21980..22723 + 744 WP_014607315.1 DNA-binding protein -
LZ754_RS12230 (LZ754_12230) 23076..23312 + 237 WP_013087968.1 antitoxin MazE family protein -
LZ754_RS12235 (LZ754_12235) 23309..23636 + 328 Protein_29 type II toxin-antitoxin system PemK/MazF family toxin -
LZ754_RS12240 (LZ754_12240) 23741..24184 - 444 WP_014607318.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..26361 26361


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-88)

Antitoxin

Protein of unknown function DUF6290

(1-70)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10221.85 Da        Isoelectric Point: 9.9871

>T230972 WP_234500012.1 NZ_CP090512:c19497-19228 [Xylella fastidiosa subsp. multiplex]
MAWKVELSSLAPKNLDQLDPQIALRVLSFLHERVAPLDDPRSIGESLKGSRLGEFWKYRVGDYRIISSIEDGALRILVVK
IGNRREVYR

Download         Length: 270 bp

>T230972 NZ_CP125736:132218-132367 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8686.80 Da        Isoelectric Point: 4.2465

>AT230972 WP_038211605.1 NZ_CP090512:c19711-19481 [Xylella fastidiosa subsp. multiplex]
MASVSLRLPDEVTQRLENLAALTGRSKTFYMVEAIREHIDDLEDLYLAERELEAIRSGNSQTVPLEEVMQRYGMEG

Download         Length: 231 bp

>AT230972 NZ_CP125736:c132173-132114 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A060HE94

References