Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2599092..2599775 Replicon chromosome
Accession NZ_CP090511
Organism Xylella fastidiosa subsp. multiplex strain Oak 35874

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LZ754_RS11980 Protein ID WP_004086858.1
Coordinates 2599092..2599520 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LZ754_RS11985 Protein ID WP_004086856.1
Coordinates 2599521..2599775 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ754_RS11950 (LZ754_11950) 2595646..2596407 - 762 WP_004085598.1 Bax inhibitor-1/YccA family protein -
LZ754_RS11975 (LZ754_11975) 2597608..2599002 + 1395 WP_038211141.1 hypothetical protein -
LZ754_RS11980 (LZ754_11980) 2599092..2599520 - 429 WP_004086858.1 type II toxin-antitoxin system VapC family toxin Toxin
LZ754_RS11985 (LZ754_11985) 2599521..2599775 - 255 WP_004086856.1 hypothetical protein Antitoxin
LZ754_RS11990 (LZ754_11990) 2599900..2600442 + 543 WP_004086854.1 hypothetical protein -
LZ754_RS11995 (LZ754_11995) 2600763..2601136 - 374 Protein_2355 DUF596 domain-containing protein -
LZ754_RS12000 (LZ754_12000) 2601148..2601453 - 306 WP_228762248.1 DUF769 domain-containing protein -
LZ754_RS12005 (LZ754_12005) 2601652..2602044 - 393 WP_038211775.1 DUF596 domain-containing protein -
LZ754_RS12010 (LZ754_12010) 2602055..2602312 - 258 WP_021358680.1 hemagglutinin -
LZ754_RS12015 (LZ754_12015) 2602585..2602968 - 384 WP_004086848.1 DUF596 domain-containing protein -
LZ754_RS12020 (LZ754_12020) 2602973..2604010 - 1038 WP_004086846.1 DUF769 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15641.79 Da        Isoelectric Point: 5.1634

>T230970 WP_004086858.1 NZ_CP090511:c2599520-2599092 [Xylella fastidiosa subsp. multiplex]
MIVLDTNVVSEAMKPEPDAAVRTWLNEQMSVTLYLSSVTLSELLFGIAVLPTSKRKDMLARTLDGLLDLFNERVLPFDTD
AARHYAELAVKARNNGRGFPTPDGYIAAIAASRGYIVASRDTSAYESSGVQVINPWQYSKQT

Download         Length: 429 bp

>T230970 NZ_CP125736:c72403-71987 [Klebsiella pneumoniae]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9601.95 Da        Isoelectric Point: 6.4732

>AT230970 WP_004086856.1 NZ_CP090511:c2599775-2599521 [Xylella fastidiosa subsp. multiplex]
MAMLTVRNLPDEVHRALRVRAATHGRSTEAEVREILTNIVKPDERVRIGDALAILGREIGLNNEDFTTFDKVRDKTQAEP
MRFE

Download         Length: 255 bp

>AT230970 NZ_CP125736:c72630-72400 [Klebsiella pneumoniae]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References