Detailed information of TA system TA230967

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-dnstrm_HI1420
• Location: 1897636..1898228
• Replicon: chromosome
• Accession: NZ_CP090511
• Organism: Xylella fastidiosa subsp. multiplex strain Oak 35874

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: LZ754_RS08880
• Protein ID: WP_154414943.1
• Coordinates: 1897636..1897932 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: LZ754_RS08885
• Protein ID: WP_004085592.1
• Coordinates: 1897935..1898228 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ754_RS08860 (LZ754_08860)	1893147..1894151	-	1005	WP_234499743.1	peptidase	-
LZ754_RS08865 (LZ754_08865)	1894656..1895819	-	1164	WP_234499744.1	tail fiber protein	-
LZ754_RS08870 (LZ754_08870)	1895823..1896383	-	561	WP_004084996.1	DUF2612 domain-containing protein	-
LZ754_RS08875 (LZ754_08875)	1896380..1897525	-	1146	WP_234499695.1	baseplate J/gp47 family protein	-
LZ754_RS08880 (LZ754_08880)	1897636..1897932	+	297	WP_154414943.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LZ754_RS08885 (LZ754_08885)	1897935..1898228	+	294	WP_004085592.1	putative addiction module antidote protein	Antitoxin
LZ754_RS08890 (LZ754_08890)	1898284..1898637	-	354	WP_020851652.1	hypothetical protein	-
LZ754_RS08895 (LZ754_08895)	1898634..1899275	-	642	WP_040123250.1	Gp138 family membrane-puncturing spike protein	-
LZ754_RS08900 (LZ754_08900)	1899272..1900102	-	831	WP_027700631.1	hypothetical protein	-
LZ754_RS08905 (LZ754_08905)	1900099..1900416	-	318	WP_004085001.1	hypothetical protein	-
LZ754_RS08910 (LZ754_08910)	1900416..1901186	-	771	WP_234499745.1	hypothetical protein	-
LZ754_RS08915 (LZ754_08915)	1901274..1901573	+	300	WP_234499746.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LZ754_RS08920 (LZ754_08920)	1901577..1901885	+	309	WP_004085003.1	putative addiction module antidote protein	-
LZ754_RS08925 (LZ754_08925)	1901959..1902870	-	912	WP_234499698.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1886694..1943810	57116

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-96)

Antitoxin

• Uncharacterized protein HI1420 (3-93)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11188.75 Da
• Isoelectric Point: 10.2636

>T230967 WP_154414943.1 NZ_CP090511:1897636-1897932 [Xylella fastidiosa subsp. multiplex]
MIDLKQTDTFRKWREKLKDARARSAIASRLDRLAFGHVGDAEPVGKGISELRINYGPGYRVYFQRRGDTIYLLLCGGDKG
SQARDIKTALRLSEQWSE

Nucleotide

• Length: 297 bp

>T230967 NZ_CP125734:c4655566-4655246 [Klebsiella pneumoniae]
ATGCACATTTCAACTGTACCGGCCAAGGAGTCGGTTTCGTCACGTCTGTCGCCCGTGCAGGTCTGGCAGCAACTTTTAAC
GTATCTGCTGAATCACCATTACGGCCTGACGCTTAACGACACGCCATTCCATAACGACACGGCCATTCAGGAGCATATTG
AAGCTGGTATTGCACTTGCTGATGCAGTGAATTTCCTGGTGGAACGCTATGAACTGGTACGCACTGACCGTAAGGGATTC
ACTTGGCAAGATCAGACACCATTCCTGACCACCACCGATATTCTCAGAGCCAGACGAGCTACCGGAATAATAAATACTTG
A

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10246.59 Da
• Isoelectric Point: 5.6232

>AT230967 WP_004085592.1 NZ_CP090511:1897935-1898228 [Xylella fastidiosa subsp. multiplex]
MTEKLTSYDPAEDLTTDQAIADFMAAAFGTNDPAYVAHALGVVARAKGMTQIASQTGLSREQLYRSFSAEGNPTLRTTLA
VMKALGIELSAKPSGVH

Nucleotide

• Length: 294 bp

>AT230967 NZ_CP125734:c4655926-4655603 [Klebsiella pneumoniae]
ATGCCATTCACACTACCCAATGAATGGGGGCTACAAAGCGATATCACCCCACGATTTGGCGCAAGATTAGTTCAGGAAGG
CAACCGGCTGCATTACCTGGCTGACAGGGCTGGTTTGACGGGGGAAATTACCCCGAAGCAACTGCAGAAACTGGCTCAAA
CTTTCCCGCTGTTTATCAGTCAATTGGAAGCAATGCTGCGCTCCGGTGAGCTAAATTCACAGCAGCAACATCAGGTGACC
ATTCAACTTGCGAGTCTAACCTGTATAGCTGATACCCGTGGTAGCTGCGGCTACGTTTACATTTCTATTTATCCAACCCC
TTAA