Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RHH(antitoxin) |
| Location | 1688128..1688650 | Replicon | chromosome |
| Accession | NZ_CP090511 | ||
| Organism | Xylella fastidiosa subsp. multiplex strain Oak 35874 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | LZ754_RS07820 | Protein ID | WP_004085905.1 |
| Coordinates | 1688363..1688650 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A060HDF9 |
| Locus tag | LZ754_RS07815 | Protein ID | WP_004085758.1 |
| Coordinates | 1688128..1688370 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZ754_RS07785 (LZ754_07785) | 1683530..1683805 | + | 276 | WP_234499726.1 | hypothetical protein | - |
| LZ754_RS07790 (LZ754_07790) | 1684004..1684930 | - | 927 | WP_234499727.1 | Grx4 family monothiol glutaredoxin | - |
| LZ754_RS07795 (LZ754_07795) | 1685029..1685772 | + | 744 | WP_225621865.1 | polysaccharide deacetylase family protein | - |
| LZ754_RS07800 (LZ754_07800) | 1686416..1686607 | - | 192 | WP_027700471.1 | hypothetical protein | - |
| LZ754_RS07805 (LZ754_07805) | 1687025..1687444 | - | 420 | WP_004085763.1 | putative toxin-antitoxin system toxin component, PIN family | - |
| LZ754_RS07810 (LZ754_07810) | 1687444..1687683 | - | 240 | WP_004085761.1 | ribbon-helix-helix domain-containing protein | - |
| LZ754_RS07815 (LZ754_07815) | 1688128..1688370 | + | 243 | WP_004085758.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| LZ754_RS07820 (LZ754_07820) | 1688363..1688650 | + | 288 | WP_004085905.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LZ754_RS07825 (LZ754_07825) | 1688738..1689304 | + | 567 | WP_004085755.1 | recombinase family protein | - |
| LZ754_RS07830 (LZ754_07830) | 1689321..1690553 | - | 1233 | WP_140160997.1 | RNA-guided endonuclease TnpB family protein | - |
| LZ754_RS07835 (LZ754_07835) | 1690547..1691173 | - | 627 | WP_140160998.1 | IS607 family transposase | - |
| LZ754_RS07840 (LZ754_07840) | 1691403..1692677 | - | 1275 | WP_012337985.1 | pyridoxal phosphate-dependent aminotransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1686416..1707908 | 21492 | |
| - | flank | IS/Tn | - | - | 1688738..1689304 | 566 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11159.64 Da Isoelectric Point: 5.9570
>T230966 WP_004085905.1 NZ_CP090511:1688363-1688650 [Xylella fastidiosa subsp. multiplex]
MAKSYRLTPLAEADLEEIWFYTFRHWSIEQADSYHRSLVAVFEGLAAGTKQGCPSVLPDFNKYLCGSHVVYFMDYADHLD
IIRILHQRQDTERYL
MAKSYRLTPLAEADLEEIWFYTFRHWSIEQADSYHRSLVAVFEGLAAGTKQGCPSVLPDFNKYLCGSHVVYFMDYADHLD
IIRILHQRQDTERYL
Download Length: 288 bp
>T230966 NZ_CP125734:c4619496-4618963 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTATTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTATTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8774.77 Da Isoelectric Point: 6.9881
>AT230966 WP_004085758.1 NZ_CP090511:1688128-1688370 [Xylella fastidiosa subsp. multiplex]
MSRNTSVALGPHFTSFIDAQVQGGRYGTASDVVRAGLRLLEEHETKVKALQDALNVGHQSGEPRPFDSEVFLSRMHTQHG
MSRNTSVALGPHFTSFIDAQVQGGRYGTASDVVRAGLRLLEEHETKVKALQDALNVGHQSGEPRPFDSEVFLSRMHTQHG
Download Length: 243 bp
>AT230966 NZ_CP125734:c4619773-4619507 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|