Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 643432..643973 Replicon chromosome
Accession NZ_CP090511
Organism Xylella fastidiosa subsp. multiplex strain Oak 35874

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LZ754_RS02805 Protein ID WP_027700637.1
Coordinates 643650..643973 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LZ754_RS02800 Protein ID WP_027700636.1
Coordinates 643432..643653 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ754_RS02755 (LZ754_02755) 638619..638747 - 129 WP_004084291.1 hypothetical protein -
LZ754_RS02760 (LZ754_02760) 639143..639454 - 312 WP_038230964.1 single-stranded DNA-binding protein -
LZ754_RS02765 (LZ754_02765) 639495..640670 - 1176 WP_234499890.1 replication initiation factor domain-containing protein -
LZ754_RS02770 (LZ754_02770) 641455..641604 - 150 WP_228762570.1 hypothetical protein -
LZ754_RS02775 (LZ754_02775) 641624..641887 - 264 WP_038210414.1 hypothetical protein -
LZ754_RS02780 (LZ754_02780) 641880..642050 - 171 WP_155238088.1 hypothetical protein -
LZ754_RS02785 (LZ754_02785) 642054..642320 - 267 WP_080654487.1 hypothetical protein -
LZ754_RS02790 (LZ754_02790) 642345..642668 - 324 WP_234499891.1 hypothetical protein -
LZ754_RS02795 (LZ754_02795) 642806..643183 + 378 WP_234499892.1 DUF3693 domain-containing protein -
LZ754_RS02800 (LZ754_02800) 643432..643653 + 222 WP_027700636.1 antitoxin MazE family protein Antitoxin
LZ754_RS02805 (LZ754_02805) 643650..643973 + 324 WP_027700637.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LZ754_RS02810 (LZ754_02810) 644007..644837 - 831 WP_027700638.1 site-specific integrase -
LZ754_RS02815 (LZ754_02815) 645099..645368 + 270 WP_027700639.1 septation ring formation regulator EzrA -
LZ754_RS02820 (LZ754_02820) 645383..646516 - 1134 WP_080654478.1 zonular occludens toxin domain-containing protein -
LZ754_RS02825 (LZ754_02825) 646516..646857 - 342 WP_027700640.1 DUF2523 family protein -
LZ754_RS02830 (LZ754_02830) 646861..648288 - 1428 WP_234499893.1 virulence factor TspB C-terminal domain-related protein -
LZ754_RS02835 (LZ754_02835) 648388..648612 - 225 WP_234499894.1 major capsid protein -
LZ754_RS02840 (LZ754_02840) 648621..648827 - 207 WP_071870022.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 633381..654791 21410


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(9-72)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11799.86 Da        Isoelectric Point: 7.9848

>T230962 WP_027700637.1 NZ_CP090511:643650-643973 [Xylella fastidiosa subsp. multiplex]
MIQRGDLVTVSLQGDYGKPRPALIVQSDLLTELDSVVLCPVTSDLRNAIFRVTVEPTAANGLRTLSQVMVDKISTLPRNK
ISEPFGRLNDERMKAIERALLLIIGII

Download         Length: 324 bp

>T230962 NZ_CP125734:c2629930-2628608 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGAGAGCAGATGTTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8458.64 Da        Isoelectric Point: 9.3510

>AT230962 WP_027700636.1 NZ_CP090511:643432-643653 [Xylella fastidiosa subsp. multiplex]
MTSTHRPDSKIVHHREQMRAAGLRPMQLWVPDTRTPEFAAEIRSQCRALKGDQAEADALRFTEKTMTHIEGWK

Download         Length: 222 bp

>AT230962 NZ_CP125734:c2630196-2629930 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References