Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 476419..477005 Replicon chromosome
Accession NZ_CP090511
Organism Xylella fastidiosa subsp. multiplex strain Oak 35874

Toxin (Protein)


Gene name hicA Uniprot ID Q87BV5
Locus tag LZ754_RS02015 Protein ID WP_004089517.1
Coordinates 476751..477005 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID B2I6C9
Locus tag LZ754_RS02010 Protein ID WP_004085025.1
Coordinates 476419..476754 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ754_RS01980 (LZ754_01980) 473193..473726 - 534 WP_050765457.1 terminase small subunit -
LZ754_RS01985 (LZ754_01985) 473899..474123 - 225 WP_038230183.1 hypothetical protein -
LZ754_RS01990 (LZ754_01990) 474125..474586 - 462 WP_038211744.1 hypothetical protein -
LZ754_RS01995 (LZ754_01995) 474576..474905 - 330 WP_004085022.1 phage holin family protein -
LZ754_RS02000 (LZ754_02000) 474898..475398 - 501 WP_234499714.1 lysozyme -
LZ754_RS02005 (LZ754_02005) 475498..476229 - 732 WP_234499874.1 site-specific DNA-methyltransferase -
LZ754_RS02010 (LZ754_02010) 476419..476754 - 336 WP_004085025.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LZ754_RS02015 (LZ754_02015) 476751..477005 - 255 WP_004089517.1 type II toxin-antitoxin system HicA family toxin Toxin
LZ754_RS02020 (LZ754_02020) 477085..477780 - 696 Protein_384 hypothetical protein -
LZ754_RS02025 (LZ754_02025) 477723..478070 - 348 WP_160168467.1 hypothetical protein -
LZ754_RS02030 (LZ754_02030) 478259..479527 + 1269 WP_080715089.1 DNA polymerase -
LZ754_RS02035 (LZ754_02035) 479527..479802 + 276 WP_234499712.1 VRR-NUC domain-containing protein -
LZ754_RS02040 (LZ754_02040) 479804..480130 - 327 WP_004083464.1 hypothetical protein -
LZ754_RS02045 (LZ754_02045) 480215..481633 + 1419 WP_234499875.1 DEAD/DEAH box helicase -
LZ754_RS02050 (LZ754_02050) 481630..481794 + 165 WP_200873170.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 446613..485552 38939


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-80)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9639.14 Da        Isoelectric Point: 11.2766

>T230961 WP_004089517.1 NZ_CP090511:c477005-476751 [Xylella fastidiosa subsp. multiplex]
MKRKHAKTLSAIYTRPVSANIQWRDIEALFVELGAKVEEREGSRMLVRLFGERRIFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Download         Length: 255 bp

>T230961 NZ_CP125734:1817996-1818098 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12324.07 Da        Isoelectric Point: 5.6556

>AT230961 WP_004085025.1 NZ_CP090511:c476754-476419 [Xylella fastidiosa subsp. multiplex]
MKNIMTIESFKAIITYDPEIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACKEDSVEPRKCYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEVHT

Download         Length: 336 bp

>AT230961 NZ_CP125734:c1818105-1817960 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q87BV5

Antitoxin

Source ID Structure
AlphaFold DB A0A060HAK5

References