Detailed information of TA system TA230957

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-dnstrm_HI1420
• Location: 1373814..1374406
• Replicon: chromosome
• Accession: NZ_CP090510
• Organism: Xylella fastidiosa subsp. multiplex strain LA-Y3C

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: A0A060HCK8
• Locus tag: LZ759_RS06030
• Protein ID: WP_004085590.1
• Coordinates: 1373814..1374110 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: LZ759_RS06035
• Protein ID: WP_004085592.1
• Coordinates: 1374113..1374406 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ759_RS06005 (LZ759_06005)	1368984..1369952	+	969	WP_004084992.1	hypothetical protein	-
LZ759_RS06010 (LZ759_06010)	1370211..1370657	+	447	WP_004084994.1	hypothetical protein	-
LZ759_RS06015 (LZ759_06015)	1370761..1372005	-	1245	WP_234545655.1	tail fiber protein	-
LZ759_RS06020 (LZ759_06020)	1372009..1372569	-	561	WP_140161929.1	DUF2612 domain-containing protein	-
LZ759_RS06025 (LZ759_06025)	1372566..1373711	-	1146	WP_234545657.1	baseplate J/gp47 family protein	-
LZ759_RS06030 (LZ759_06030)	1373814..1374110	+	297	WP_004085590.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LZ759_RS06035 (LZ759_06035)	1374113..1374406	+	294	WP_004085592.1	putative addiction module antidote protein	Antitoxin
LZ759_RS06040 (LZ759_06040)	1374462..1374815	-	354	WP_027700632.1	hypothetical protein	-
LZ759_RS06045 (LZ759_06045)	1374812..1375453	-	642	WP_012382583.1	Gp138 family membrane-puncturing spike protein	-
LZ759_RS06050 (LZ759_06050)	1375450..1376280	-	831	WP_128734736.1	hypothetical protein	-
LZ759_RS06055 (LZ759_06055)	1376277..1376594	-	318	WP_012382585.1	hypothetical protein	-
LZ759_RS06060 (LZ759_06060)	1376594..1377364	-	771	WP_140160955.1	hypothetical protein	-
LZ759_RS06065 (LZ759_06065)	1377475..1377702	+	228	WP_004091377.1	DUF6290 family protein	-
LZ759_RS06070 (LZ759_06070)	1377686..1377952	+	267	WP_004087087.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1370761..1436093	65332

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-94)

Antitoxin

• Uncharacterized protein HI1420 (3-93)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11169.70 Da
• Isoelectric Point: 10.0610

>T230957 WP_004085590.1 NZ_CP090510:1373814-1374110 [Xylella fastidiosa subsp. multiplex]
MIELKQTDTFRKWREKLKDARARSAIASRLDRLAFGHVGDAEPVGKGVSELRINYGPGYRVYFQRRGDTIYLLLCGGDKG
SQARDIKTALHLSEQWSE

Nucleotide

• Length: 297 bp

>T230957 NZ_CP125734:332031-332399 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10246.59 Da
• Isoelectric Point: 5.6232

>AT230957 WP_004085592.1 NZ_CP090510:1374113-1374406 [Xylella fastidiosa subsp. multiplex]
MTEKLTSYDPAEDLTTDQAIADFMAAAFGTNDPAYVAHALGVVARAKGMTQIASQTGLSREQLYRSFSAEGNPTLRTTLA
VMKALGIELSAKPSGVH

Nucleotide

• Length: 294 bp

>AT230957 NZ_CP125734:331813-332034 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A060HCK8