Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/- |
| Location | 474410..474996 | Replicon | chromosome |
| Accession | NZ_CP090510 | ||
| Organism | Xylella fastidiosa subsp. multiplex strain LA-Y3C | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q87BV5 |
| Locus tag | LZ759_RS01975 | Protein ID | WP_004089517.1 |
| Coordinates | 474742..474996 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | B2I6C9 |
| Locus tag | LZ759_RS01970 | Protein ID | WP_004085025.1 |
| Coordinates | 474410..474745 (-) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZ759_RS01940 (LZ759_01940) | 471185..471718 | - | 534 | WP_004088896.1 | terminase small subunit | - |
| LZ759_RS01945 (LZ759_01945) | 471891..472115 | - | 225 | WP_012337656.1 | hypothetical protein | - |
| LZ759_RS01950 (LZ759_01950) | 472117..472578 | - | 462 | WP_140162026.1 | hypothetical protein | - |
| LZ759_RS01955 (LZ759_01955) | 472568..472897 | - | 330 | WP_004085022.1 | phage holin family protein | - |
| LZ759_RS01960 (LZ759_01960) | 472890..473390 | - | 501 | WP_234545836.1 | lysozyme | - |
| LZ759_RS01965 (LZ759_01965) | 473489..474220 | - | 732 | WP_140160983.1 | site-specific DNA-methyltransferase | - |
| LZ759_RS01970 (LZ759_01970) | 474410..474745 | - | 336 | WP_004085025.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LZ759_RS01975 (LZ759_01975) | 474742..474996 | - | 255 | WP_004089517.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LZ759_RS01980 (LZ759_01980) | 475076..475771 | - | 696 | Protein_375 | hypothetical protein | - |
| LZ759_RS01985 (LZ759_01985) | 476115..476273 | + | 159 | WP_234545837.1 | hypothetical protein | - |
| LZ759_RS01990 (LZ759_01990) | 476375..477517 | + | 1143 | WP_234545838.1 | DNA polymerase | - |
| LZ759_RS01995 (LZ759_01995) | 477517..477792 | + | 276 | WP_228304208.1 | VRR-NUC domain-containing protein | - |
| LZ759_RS02000 (LZ759_02000) | 477794..478120 | - | 327 | WP_004083464.1 | hypothetical protein | - |
| LZ759_RS02005 (LZ759_02005) | 478206..479624 | + | 1419 | WP_234545839.1 | DEAD/DEAH box helicase | - |
| LZ759_RS02010 (LZ759_02010) | 479621..479785 | + | 165 | WP_169709885.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 434814..483543 | 48729 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 9639.14 Da Isoelectric Point: 11.2766
>T230955 WP_004089517.1 NZ_CP090510:c474996-474742 [Xylella fastidiosa subsp. multiplex]
MKRKHAKTLSAIYTRPVSANIQWRDIEALFVELGAKVEEREGSRMLVRLFGERRIFHRPHPSPNTDKGAVESIRAWLKSN
GVTP
MKRKHAKTLSAIYTRPVSANIQWRDIEALFVELGAKVEEREGSRMLVRLFGERRIFHRPHPSPNTDKGAVESIRAWLKSN
GVTP
Download Length: 255 bp
>T230955 NZ_CP125733:c134957-134541 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12324.07 Da Isoelectric Point: 5.6556
>AT230955 WP_004085025.1 NZ_CP090510:c474745-474410 [Xylella fastidiosa subsp. multiplex]
MKNIMTIESFKAIITYDPEIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACKEDSVEPRKCYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEVHT
MKNIMTIESFKAIITYDPEIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACKEDSVEPRKCYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEVHT
Download Length: 336 bp
>AT230955 NZ_CP125733:c135184-134954 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q87BV5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A060HAK5 |