Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mqsR-graA/MqsR-HigA
Location 1734295..1734960 Replicon chromosome
Accession NZ_CP090508
Organism Xylella fastidiosa subsp. morus strain Riv11

Toxin (Protein)


Gene name mqsR Uniprot ID A0A060HKF7
Locus tag LZ758_RS08160 Protein ID WP_038230541.1
Coordinates 1734658..1734960 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LZ758_RS08155 Protein ID WP_004085172.1
Coordinates 1734295..1734570 (+) Length 92 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ758_RS08125 (LZ758_08125) 1729550..1730359 - 810 WP_234509048.1 phage tail sheath family protein -
LZ758_RS08130 (LZ758_08130) 1730424..1732016 - 1593 WP_040123119.1 tail fiber domain-containing protein -
LZ758_RS08135 (LZ758_08135) 1732024..1732581 - 558 WP_027700436.1 phage tail protein I -
LZ758_RS08140 (LZ758_08140) 1732574..1733467 - 894 WP_234056296.1 baseplate J/gp47 family protein -
LZ758_RS08145 (LZ758_08145) 1733467..1733790 - 324 WP_228304176.1 GPW/gp25 family protein -
LZ758_RS08150 (LZ758_08150) 1734003..1734284 + 282 WP_004085174.1 type II toxin-antitoxin system RelE/ParE family toxin -
LZ758_RS08155 (LZ758_08155) 1734295..1734570 + 276 WP_004085172.1 HigA family addiction module antitoxin Antitoxin
LZ758_RS08160 (LZ758_08160) 1734658..1734960 + 303 WP_038230541.1 type II toxin-antitoxin system MqsR family toxin Toxin
LZ758_RS08165 (LZ758_08165) 1734963..1735364 + 402 WP_004090697.1 type II toxin-antitoxin system MqsA family antitoxin -
LZ758_RS08170 (LZ758_08170) 1735433..1736020 - 588 WP_040123117.1 phage baseplate assembly protein V -
LZ758_RS08175 (LZ758_08175) 1736017..1736559 - 543 WP_038230164.1 hypothetical protein -
LZ758_RS08180 (LZ758_08180) 1736535..1737056 - 522 WP_038230165.1 hypothetical protein -
LZ758_RS08185 (LZ758_08185) 1737053..1737376 - 324 WP_027700441.1 hypothetical protein -
LZ758_RS08190 (LZ758_08190) 1737327..1737635 - 309 WP_234056295.1 hypothetical protein -
LZ758_RS08195 (LZ758_08195) 1737653..1738453 - 801 WP_234509132.1 phage major capsid protein -
LZ758_RS08200 (LZ758_08200) 1738522..1738950 - 429 WP_234509050.1 hypothetical protein -
LZ758_RS08205 (LZ758_08205) 1738947..1739525 - 579 WP_234509053.1 HK97 family phage prohead protease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1724271..1764549 40278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-99)

Antitoxin

(15-64)


Sequences


Toxin        


Download         Length: 101 a.a.        Molecular weight: 10972.77 Da        Isoelectric Point: 8.0251

>T230949 WP_038230541.1 NZ_CP090508:1734658-1734960 [Xylella fastidiosa subsp. morus]
MEKGTPHYKLPVVKALVKAGKVRATATAYQGARELGIKDLTGMCAVVLALTSADFYKSMTTYTDHTLFQDVYHAKTASGD
EVYLKLTVIDDVLIVSFKEL

Download         Length: 303 bp

>T230949 NZ_CP125731:3770752-3771030 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10072.68 Da        Isoelectric Point: 10.2184

>AT230949 WP_004085172.1 NZ_CP090508:1734295-1734570 [Xylella fastidiosa subsp. morus]
MKRMHNPAHPGEVLREYLGELTVTNAAAKLGVSRVALSRILNGTNGISADMALRLEDALGTSAEMWAAMQFKYDLWVASQ
QPRPKITRLHV

Download         Length: 276 bp

>AT230949 NZ_CP125731:3770489-3770749 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A060HKF7


Antitoxin

Source ID Structure

References