Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | shpAB/BrnT-BrnA |
| Location | 1454761..1455343 | Replicon | chromosome |
| Accession | NZ_CP090508 | ||
| Organism | Xylella fastidiosa subsp. morus strain Riv11 | ||
Toxin (Protein)
| Gene name | shpA | Uniprot ID | A0A060HA48 |
| Locus tag | LZ758_RS06805 | Protein ID | WP_038229226.1 |
| Coordinates | 1455053..1455343 (-) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | shpB | Uniprot ID | A0A060HE88 |
| Locus tag | LZ758_RS06800 | Protein ID | WP_004091409.1 |
| Coordinates | 1454761..1455066 (-) | Length | 102 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LZ758_RS06765 (LZ758_06765) | 1450016..1451014 | + | 999 | WP_004085391.1 | MBL fold metallo-hydrolase | - |
| LZ758_RS06770 (LZ758_06770) | 1450980..1452174 | + | 1195 | Protein_1332 | DUF5710 domain-containing protein | - |
| LZ758_RS06775 (LZ758_06775) | 1452298..1452723 | + | 426 | WP_038229235.1 | antirestriction protein | - |
| LZ758_RS06780 (LZ758_06780) | 1452991..1453248 | + | 258 | WP_038229233.1 | hypothetical protein | - |
| LZ758_RS06785 (LZ758_06785) | 1453333..1453899 | - | 567 | WP_038229232.1 | recombinase family protein | - |
| LZ758_RS06790 (LZ758_06790) | 1453987..1454274 | - | 288 | WP_038229230.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LZ758_RS06795 (LZ758_06795) | 1454267..1454509 | - | 243 | WP_004085758.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| LZ758_RS06800 (LZ758_06800) | 1454761..1455066 | - | 306 | WP_004091409.1 | BrnA antitoxin family protein | Antitoxin |
| LZ758_RS06805 (LZ758_06805) | 1455053..1455343 | - | 291 | WP_038229226.1 | BrnT family toxin | Toxin |
| LZ758_RS12245 | 1455418..1455693 | + | 276 | WP_004091404.1 | XRE family transcriptional regulator | - |
| LZ758_RS06815 (LZ758_06815) | 1455804..1456124 | + | 321 | WP_004091397.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LZ758_RS06820 (LZ758_06820) | 1456254..1456580 | + | 327 | WP_004091396.1 | DNA-binding protein | - |
| LZ758_RS06825 (LZ758_06825) | 1456722..1457648 | - | 927 | WP_051606204.1 | hypothetical protein | - |
| LZ758_RS06830 (LZ758_06830) | 1458054..1458470 | - | 417 | WP_038229223.1 | IS200/IS605 family transposase | - |
| LZ758_RS06835 (LZ758_06835) | 1458493..1459650 | + | 1158 | WP_038229247.1 | RNA-guided endonuclease TnpB family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1451716..1473913 | 22197 | |
| - | inside | IScluster/Tn | - | - | 1453333..1459650 | 6317 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11304.62 Da Isoelectric Point: 6.0917
>T230947 WP_038229226.1 NZ_CP090508:c1455343-1455053 [Xylella fastidiosa subsp. morus]
VERYFEWDDKKAESNFRKHGIRFDEAALAFDDPFAVSEQNRIENGEQRWQTIGMAGGCLLLLVAHTVHFEDDGIEVVRII
SARRVDRKERRRYEHG
VERYFEWDDKKAESNFRKHGIRFDEAALAFDDPFAVSEQNRIENGEQRWQTIGMAGGCLLLLVAHTVHFEDDGIEVVRII
SARRVDRKERRRYEHG
Download Length: 291 bp
>T230947 NZ_CP125731:3520742-3520960 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 102 a.a. Molecular weight: 11684.43 Da Isoelectric Point: 9.4870
>AT230947 WP_004091409.1 NZ_CP090508:c1455066-1454761 [Xylella fastidiosa subsp. morus]
MNMVRYKQSELPPLTEERKAELKALAKKPDSEIDYSDIPPLDESFWARAVPNPFFKPVKTHASVRIDSDVLAWLKSQGKG
YQTRMNAILREAMLRSLHQQE
MNMVRYKQSELPPLTEERKAELKALAKKPDSEIDYSDIPPLDESFWARAVPNPFFKPVKTHASVRIDSDVLAWLKSQGKG
YQTRMNAILREAMLRSLHQQE
Download Length: 306 bp
>AT230947 NZ_CP125731:3520342-3520716 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A060HA48 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A060HE88 |